{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:06:02Z","timestamp":1792069562291,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T00:00:00Z","timestamp":1211328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Observational evidence suggests that dietary glycemic load may be one environmental factor contributing to the variation in acne prevalence worldwide. To investigate the effect of a low glycemic load (LGL) diet on endocrine aspects of\n                    <jats:italic>acne vulgaris<\/jats:italic>\n                    , 12 male acne sufferers (17.0 \u00b1 0.4 years) completed a parallel, controlled feeding trial involving a 7\u2010day admission to a housing facility. Subjects consumed either an LGL diet (\n                    <jats:italic>n =<\/jats:italic>\n                    7; 25% energy from protein and 45% from carbohydrates) or a high glycemic load (HGL) diet (\n                    <jats:italic>n<\/jats:italic>\n                    = 5; 15% energy from protein, 55% energy from carbohydrate). Study outcomes included changes in the homeostasis model assessment of insulin resistance (HOMA\u2010IR), sex hormone binding globulin (SHBG), free androgen index (FAI), insulin\u2010like growth factor\u2010I (IGF\u2010I), and its binding proteins (IGFBP\u2010I and IGFBP\u20103). Changes in HOMA\u2010IR were significantly different between groups at day 7 (\u20130.57 for LGL\n                    <jats:italic>vs.<\/jats:italic>\n                    0.14 for HGL,\n                    <jats:italic>p =<\/jats:italic>\n                    0.03). SHBG levels decreased significantly from baseline in the HGL group (\n                    <jats:italic>p =<\/jats:italic>\n                    0.03), while IGFBP\u2010I and IGFBP\u20103 significantly increased (\n                    <jats:italic>p =<\/jats:italic>\n                    0.03 and 0.03, respectively) in the LGL group. These results suggest that increases in dietary glycemic load may augment the biological activity of sex hormones and IGF\u2010I, suggesting that these diets may aggravate potential factors involved in acne development.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.200700307","type":"journal-article","created":{"date-parts":[[2008,5,21]],"date-time":"2008-05-21T10:19:29Z","timestamp":1211365169000},"page":"718-726","source":"Crossref","is-referenced-by-count":72,"title":["A pilot study to determine the short\u2010term effects of a low glycemic load diet on hormonal markers of acne: A nonrandomized, parallel, controlled feeding trial"],"prefix":"10.1002","volume":"52","author":[{"given":"Robyn","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henna","family":"M\u00e4kel\u00e4inen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Roper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Braue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Varigos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,6,6]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"97","article-title":"Acne: An overview of clinical research findings","volume":"15","author":"Thiboutot D.","year":"1997","journal-title":"Adv. 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