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The higher potency of quercetin was also observed downstream on the level of the mitogen\u2010activated protein kinase (MAPK) cascade. In addition, delphinidin, quercetin and (\u2013)\u2010epigallocatechin\u20103\u2010gallate (EGCG) were found to suppress the phosphorylation of the ErbB2 receptor, with delphinidin exhibiting the strongest inhibitory properties. Their potency to suppress the ErbB2 receptor phosphorylation can be summarised as delphinidin &gt; EGCG &gt; quercetin. The effectiveness of delphinidin against the EGFR and the ErbB2 receptor was comparable, indicating a broader spectrum of activity against receptor tyrosine kinases. At low micromolar concentrations delphinidin showed some preference towards the ErbB2 receptor. In summary, quercetin and delphinidin appear to differ in their activity profile towards the ErbB receptor family members. Whereas quercetin was most effective against the EGFR, delphinidin exhibited some preference towards the ErbB2 receptor.<\/jats:p>","DOI":"10.1002\/mnfr.200800026","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T13:24:27Z","timestamp":1215696267000},"page":"815-822","source":"Crossref","is-referenced-by-count":51,"title":["Comparison of delphinidin, quercetin and (\u2013)\u2010epigallocatechin\u20103\u2010gallate as inhibitors of the EGFR and the ErbB2 receptor phosphorylation"],"prefix":"10.1002","volume":"52","author":[{"given":"Diana","family":"Fridrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Teller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Esselen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Pahlke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Marko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,14]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20158"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh052"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70312-9"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19971001)67:1<55::AID-JCB6>3.0.CO;2-V"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0009100"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200400034"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200400086"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.10.110194.001343"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/35052073"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/annonc\/12.suppl_1.S3","article-title":"The basic biology of HER2","volume":"12","author":"Rubin I.","year":"2001","journal-title":"Ann. 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