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Major allergens that induce IgE\u2010responses in peanut\u2010sensitive patients are Ara h 1, Ara h 2 and Ara h 3\/4. In order to identify hypoallergenic peanuts, commercially locally available peanut varieties were screened for their allergen content. Ara h 1\u2010deficient peanuts from Southeast Asia were identified by SDS\u2010PAGE, immunoblotting, inhibition assays and ELISA. 2\u2010D PAGE analyses demonstrated the different compositions of the tested extracts and revealed a number of variations of the allergen patterns of peanuts from different varieties. Mediator release experiments of these peanut extracts demonstrated similar allergenicities as compared with standard peanut extract. These results indicate that the allergenicity of peanuts with reduced Ara h 1 content might be compensated by the other allergens, and thus do not necessarily cause a reduction of allergenicity.<\/jats:p>","DOI":"10.1002\/mnfr.200900072","type":"journal-article","created":{"date-parts":[[2009,10,28]],"date-time":"2009-10-28T13:25:49Z","timestamp":1256736349000},"page":"381-387","source":"Crossref","is-referenced-by-count":29,"title":["Peanut varieties with reduced Ara h 1 content indicating no reduced allergenicity"],"prefix":"10.1002","volume":"54","author":[{"given":"Susanne","family":"Krause","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ties","family":"Latendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Darcan\u2010Nicolaisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Reese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottmar","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf\u2010Meinhard","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,3,5]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"European Union. 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