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The present study was set up to investigate the biological functions of polymethoxystilbenes <jats:bold>2<\/jats:bold> and <jats:bold>3<\/jats:bold>, recently found in our lab as antiangiogenic agents, on a well\u2010defined swine granulosa cell model. Proliferative activity and effects on steroidogenesis were evaluated, as well as the effect on granulosa cell vascular endothelial growth factor (VEGF) production, since these cells in basic conditions synthesize the main proangiogenic peptide. Moreover, we considered the effect of these two resveratrol analogues on granulosa cell redox status. Analogue <jats:bold>3<\/jats:bold> inhibited granulosa cell growth, while it stimulated steroidogenesis. A similar effect was displayed by <jats:bold>2<\/jats:bold> on estradiol 17\u03b2 production and cell proliferation at the highest concentration tested. On the other hand, at the same dosage <jats:bold>2<\/jats:bold> decreased progesterone levels. Both analogues inhibited VEGF output. Granulosa cell redox status was unaffected by resveratrol analogue <jats:bold>2<\/jats:bold> while the highest concentration of <jats:bold>3<\/jats:bold> stimulated free radicals generation and scavenging enzyme activities. The overall results indicate that analogue <jats:bold>3<\/jats:bold> is the more powerful compound, thus suggesting that a slight modification in the structure markedly increases effectiveness. These data could be useful to develop more active resveratrol analogues for therapeutic use.<\/jats:p>","DOI":"10.1002\/mnfr.200900320","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T14:10:24Z","timestamp":1265379024000},"source":"Crossref","is-referenced-by-count":34,"title":["Biological effects on granulosa cells of hydroxylated and methylated resveratrol analogues"],"prefix":"10.1002","volume":"54","author":[{"given":"Giuseppina","family":"Basini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tringali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Baioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Bussolati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Spatafora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Grasselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,7,22]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"348","article-title":"Polyphenols, dietary sources and bioavailability","volume":"43","author":"D'Archivio M.","year":"2007","journal-title":"Ann. 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