{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:33:43Z","timestamp":1773779623578,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T00:00:00Z","timestamp":1273536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grant-in-Aid for Young Scientists","award":["21792123"],"award-info":[{"award-number":["21792123"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2010,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>IL\u20106 is well recognized to be a potent bone resorptive agent and thus in the development of periodontal disease. Epigallocatechin gallate (EGCG) and epicatechin gallate (ECG), the major catechins in green tea, and theaflavin\u20103,3\u2032\u2010digallate (TFDG), polyphenol in black tea, have multiple beneficial effects, but the effects of catechins and theaflavins on IL\u20106 production in human gingival fibroblasts (HGFs) are not known. In this study, we investigated the mechanisms by which EGCG, ECG, and TFDG inhibit tumor necrosis factor superfamily 14 (TNFSF14)\u2010induced IL\u20106 production in HGFs. We detected TNFSF14 mRNA expression in human diseased periodontal tissues. TNFSF14 increased IL\u20106 production in HGFs in a concentration\u2010dependent manner. EGCG, ECG, and TFDG prevented TNFSF14\u2010mediated IL\u20106 production in HGFs. EGCG, ECG, and TFDG prevented TNFSF14\u2010induced extracellular signal\u2010regulated kinase (ERK), c\u2010Jun N\u2010terminal kinase (JNK), and nuclear factor\u2010\u03baB activation in HGFs. Inhibitors of ERK, JNK, and nuclear factor\u2010\u03baB decreased TNFSF14\u2010induced IL\u20106 production. In addition, EGCG, ECG, and TFDG attenuated TNFSF14 receptor expression on HGFs. These data provide a novel mechanism through which the green tea and black tea polyphenols could be used to provide direct benefits in periodontal disease.<\/jats:p>","DOI":"10.1002\/mnfr.200900549","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T16:20:58Z","timestamp":1273594858000},"source":"Crossref","is-referenced-by-count":39,"title":["Tea polyphenols inhibit IL\u20106 production in tumor necrosis factor superfamily 14\u2010stimulated human gingival fibroblasts"],"prefix":"10.1002","volume":"54","author":[{"given":"Yoshitaka","family":"Hosokawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikuko","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumi","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Nakae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,22]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb02310.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00821-0"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3379"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.60.12.5253-5258.1992"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02852.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02912.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03398.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03647.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01080.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01124.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00206.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(97)00504-2"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.62.1768"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1999.tb03267.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/128.12.2334"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0837"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.9.2248"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2006.00314.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2002.6556"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.1998.tb00255.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0747"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.02.052"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1159\/000097503"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.1120"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.27.1353"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706847"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2008.02.018"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.04.005"}],"container-title":["Molecular Nutrition &amp; 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