{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:51:06Z","timestamp":1789213866855,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T00:00:00Z","timestamp":1289260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NutritionNet project supported by the German Federal Ministry of Education and Research","award":["BMBF; 01EA0501"],"award-info":[{"award-number":["BMBF; 01EA0501"]}]},{"name":"Rhineland-Palatinate","award":["A4 project"],"award-info":[{"award-number":["A4 project"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Scope<\/jats:bold>: The aim of this study was to determine the amounts of polyphenols and <jats:sc>D<\/jats:sc>\u2010(\u2212)\u2010quinic acid reaching the ileostomy bags of probands (and thus the colon in healthy humans) after ingestion of apple smoothie, a beverage containing 60% cloudy apple juice and 40% apple puree.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold>: Ten healthy ileostomy subjects each ingested 0.7\u2009L of apple smoothie (a bottle). Their ileostomy bags were collected directly before and 1, 2, 4, 6 and 8\u2009h after smoothie consumption, and the polyphenol and <jats:sc>D<\/jats:sc>\u2010(\u2212)\u2010quinic acid contents of the ileostomy fluids were examined using HPLC\u2010DAD and HPLC\u2010MS\/MS. The total polyphenol and <jats:sc>D<\/jats:sc>\u2010(\u2212)\u2010quinic acid content of the apple smoothie was determined to be 1955.6\u00b1124.6\u2009mg\/0.7\u2009L, which is very high compared to cloudy apple juices. The most abundant substances found in the ileostomy bags were oligomeric procyanidins (705.6\u00b1197.9\u2009mg), <jats:sc>D<\/jats:sc>\u2010(\u2212)\u2010quinic acid (363.4\u00b1235.5\u2009mg) and 5\u2010caffeoylquinic acid (76.7\u00b126.8\u2009mg). Overall recovery of ingested polyphenols and <jats:sc>D<\/jats:sc>\u2010(\u2212)\u2010quinic acid in the ileostomy bags was 63.3\u00b116.1%.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The amounts of polyphenol and <jats:sc>D<\/jats:sc>\u2010(\u2212)\u2010quinic acids reaching the ileostomy bags are considerably higher after apple smoothie consumption than after the consumption of cloudy apple juice or cider. These results suggest that the food matrix might affect the colonic availability of polyphenols, and apple smoothies could be more effective in the prevention of chronic colon diseases than both cloudy apple juice and apple cider.<\/jats:p>","DOI":"10.1002\/mnfr.201000252","type":"journal-article","created":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T11:31:19Z","timestamp":1289302279000},"page":"368-377","source":"Crossref","is-referenced-by-count":53,"title":["Colonic availability of polyphenols and <scp>D<\/scp>\u2010(\u2212)\u2010quinic acid after apple smoothie consumption"],"prefix":"10.1002","volume":"55","author":[{"given":"Stephanie","family":"Hagl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Deusser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buelent","family":"Soyalan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Janzowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Will","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz Werner","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Rohner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Richling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,11,9]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200800457"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi361"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf049317z"},{"key":"e_1_2_6_5_2","volume-title":"Food Composition and Nutrition Tables","author":"Souci S.","year":"2005"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90423-4"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/np9904509"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(88)90169-4"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1088300"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500132"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf0346298"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.8.2073S"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf071942r"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf802757x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200500064"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2006.09.011"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0690(200103)2001:6<1137::AID-EJOC1137>3.0.CO;2-2"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0690(200107)2001:14<2735::AID-EJOC2735>3.0.CO;2-I"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1039\/an9840900263"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/jaoac\/92.3.730","article-title":"A novel method for the quantification of quinic acid in food using stable isotope dilution analysis","volume":"92","author":"Erk T.","year":"2009","journal-title":"J. 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