{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:31:38Z","timestamp":1791279098076,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T00:00:00Z","timestamp":1292371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"(LYCOCARD, integrated European project), INRA, and INSERM"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Scope:<\/jats:bold> Carotenoids are mainly stored in adipose tissue. However, nothing is known regarding the uptake of carotenoids by adipocytes. Thus, our study explored the mechanism by which lycopene and lutein, two major human plasma carotenoids, are transported.<\/jats:p><jats:p><jats:bold>Methods and results:<\/jats:bold> CD36 was a putative candidate for this uptake, 3T3\u2010L1 cells were treated with sulfosuccinimidyl oleate, a CD36\u2010specific inhibitor. sulfosuccinimidyl oleate\u2010treated cells showed a significant decrease in both lycopene and lutein uptake as compared to control cells. Their uptake was also decreased by partial inhibition of CD36 expression using siRNA, whereas the overexpression of CD36 in Cos\u20101 cells increased their uptake. Finally, the effect of CD36 on carotenoid uptake was confirmed <jats:italic>ex vivo<\/jats:italic> in cultures of adipose tissue explants from CD36<jats:sup>\u2212\/\u2212<\/jats:sup> mice, which exhibited reduced carotenoid uptake as compared to wild\u2010type mice explants.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> For the first time, we report the involvement of a transporter, CD36, in carotenoid uptake by adipocytes and adipose tissue.<\/jats:p>","DOI":"10.1002\/mnfr.201000399","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T15:48:29Z","timestamp":1292428109000},"page":"578-584","source":"Crossref","is-referenced-by-count":104,"title":["CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures"],"prefix":"10.1002","volume":"55","author":[{"given":"Myriam","family":"Moussa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwan","family":"Gouranton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Gleize","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire El","family":"Yazidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Niot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Besnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Borel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Landrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2005.10.001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnotbio.2010.04.016"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-009-0128-3"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.101451"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27712"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.10.006"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040554"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi0484320"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.272re3"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003826200"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.27.19055"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M703330200"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21514"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M708086200"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25299"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2009.01.001"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0506"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.07.021"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00231876"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760802098859"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1207\/s15327914nc4701_6"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN2000248"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.1.88"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01951559"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.8.1432"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900111"}],"container-title":["Molecular Nutrition &amp; 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