{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:16:16Z","timestamp":1783484176274,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T00:00:00Z","timestamp":1320624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Scope<\/jats:bold>: To identify genes involved in the susceptibility to iodine\u2010induced autoimmune thyroiditis.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold>: Diabetes, thyroiditis\u2010prone (BBdp) and \u2010resistant (BBc) rats were fed either a control or a high\u2010iodine diet for 9\u2009wk. Excess iodine intake increased the incidence of insulitis and thyroiditis in BBdp rats. BBdp rats fed the high\u2010iodine diet that did not develop thyroiditis had higher mRNA levels of <jats:italic>Fabp4<\/jats:italic>, <jats:italic>Cidec<\/jats:italic>, <jats:italic>perilipin<\/jats:italic>, <jats:italic>Ppar<\/jats:italic>\u03b3 and <jats:italic>Slc36a2<\/jats:italic> than BBdp rats fed the control diet and BBc rats fed either the control or the high\u2010iodine diet. BBdp rats fed the high\u2010iodine diet that did develop thyroiditis had higher mRNA levels of <jats:italic>Cidec<\/jats:italic>, <jats:italic>Icam1<\/jats:italic>, <jats:italic>Ifitm1<\/jats:italic>, and <jats:italic>Slpi<\/jats:italic> than BBdp rats fed the control diet and BBc rats fed either the control or the high\u2010iodine diet. BBdp rats that did develop thyroiditis had lower mRNA levels of <jats:italic>Fabp4<\/jats:italic>, <jats:italic>perilipin<\/jats:italic> and <jats:italic>Slc36a2<\/jats:italic> but higher mRNA levels of <jats:italic>Icam1<\/jats:italic>, <jats:italic>Ifitm1<\/jats:italic> and <jats:italic>Slpi<\/jats:italic> than BBdp that did not develop thyroiditis. Excess dietary iodine also increased the protein levels of Fabp4, Cidec and perilipin in BBdp rats.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>: Differential expression of thyroid genes in BBdp versus BBc rats caused by excess dietary iodine may be implicated in autoimmune thyroiditis and insulitis pathogenesis.<\/jats:p>","DOI":"10.1002\/mnfr.201100299","type":"journal-article","created":{"date-parts":[[2011,11,7]],"date-time":"2011-11-07T07:12:31Z","timestamp":1320649951000},"page":"1875-1886","source":"Crossref","is-referenced-by-count":5,"title":["Excess dietary iodine differentially affects thyroid gene expression in diabetes, thyroiditis\u2010prone versus \u2010resistant BioBreeding (BB) rats"],"prefix":"10.1002","volume":"55","author":[{"given":"Eleonora","family":"Swist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QiXuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunye","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don","family":"Caldwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie A.","family":"Scoggan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2009.09.001"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.08.013"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.1644"},{"key":"e_1_2_6_5_2","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/S0002-8223(21)01843-5","article-title":"A review of iodine toxicity reports","volume":"90","author":"Pennington J. 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