{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T14:40:56Z","timestamp":1788446456165,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T00:00:00Z","timestamp":1321401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"crossref","award":["NSC97-2314-B-075-027-MY2"],"award-info":[{"award-number":["NSC97-2314-B-075-027-MY2"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["VGH 98C1-016"],"award-info":[{"award-number":["VGH 98C1-016"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["VGH99-C1-056"],"award-info":[{"award-number":["VGH99-C1-056"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Liver injuries can trigger a cascade of inflammatory responses and as a result, initiate the process of hepatic regeneration and fibrogenesis. Resveratrol (RSV) has multiple health\u2010promoting benefits. This study evaluated the potential protective effects and mechanism of RSV as related to cholestatic liver injury. RSV was given (4\u2009mg\/kg\/day, i.p.) for either 3 days or 7 days after bile duct ligation (BDL) injury. RSV significantly reduced serum ALT, AST but not T\u2010bil on Day 3. At this early stage of injury, RSV significantly reduced TNF\u2010\u03b1 and IL\u20106 mRNA and decreased the number of Kupffer cells (CD68\n                    <jats:sup>+<\/jats:sup>\n                    ) recruited in the injured liver. RSV decreased hepatic fibrosis and reduced collagen I\u03b11 and TIMP\u20101 mRNA on Day 7. At the later stages of injury, RSV increased the number of Ki67\n                    <jats:sup>+<\/jats:sup>\n                    hepatocytes indicating that RSV promoted hepatocyte proliferation. Additionally, it resulted in decreased expression of 4\u2010hydroxynonenal and increased expression of the hepatocyte growth factor protein and mRNA in the RSV\u2010treated BDL group. Meanwhile, RSV reduced the mortality rate of BDL mice. In conclusion, RSV attenuated inflammation and reduced Kupffer cells activation. RSV decreased fibrosis and promoted hepatocyte regeneration, which increased the survival of BDL mice. RSV was beneficial for the treatment of cholestatic liver injury.\n                  <\/jats:p>","DOI":"10.1002\/mnfr.201100374","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T17:08:33Z","timestamp":1321463313000},"page":"1841-1849","source":"Crossref","is-referenced-by-count":66,"title":["The protective role of natural phytoalexin resveratrol on inflammation, fibrosis and regeneration in cholestatic liver injury"],"prefix":"10.1002","volume":"55","author":[{"given":"Che\u2010Chang","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Yi","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin\u2010Lung","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Hsiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Chieh","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa\u2010Yauh","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1489"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1073116"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04819.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4865"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.45.120403.095906"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2000.020005387.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007337"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/65.2.166"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00163-5"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.015"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2247"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.09.010"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/152308601317203567"},{"key":"e_1_2_6_15_2","first-page":"999","article-title":"The 3,4\u2010dihydroxyl groups are important for trans\u2010resveratrol analogs to exhibit enhanced antioxidant and apoptotic activities","volume":"24","author":"Cai Y. 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