{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:50:41Z","timestamp":1761519041954},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T00:00:00Z","timestamp":1346976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Scope<\/jats:title>The importance of folate\u2010mediated one\u2010carbon metabolism (FOCM<\/jats:styled-content>) in colorectal carcinogenesis is emphasized by observations that high dietary folate intake is associated with decreased risk of colon cancer (CC<\/jats:styled-content>) and its precursors. Additionally, polymorphisms in FOCM<\/jats:styled-content>\u2010related genes have been repeatedly associated with risk, supporting a causal relationship between folate and colorectal carcinogenesis.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>We investigated ten candidate polymorphisms with defined or probable functional impact in eight FOCM<\/jats:styled-content>\u2010related genes (SHMT<\/jats:styled-content>1, DHFR<\/jats:styled-content>, DNMT<\/jats:styled-content>1, MTHFD<\/jats:styled-content>1, MTHFR<\/jats:styled-content>, MTRR<\/jats:styled-content>, TCN<\/jats:styled-content>2, and TDG<\/jats:styled-content>) in 1609 CC<\/jats:styled-content> cases and 1974 controls for association with CC<\/jats:styled-content> risk and for interaction with dietary factors. No polymorphism was statistically significantly associated with overall risk of CC<\/jats:styled-content>. However, statistically significant interactions modifying CC<\/jats:styled-content> risk were observed for DNMT<\/jats:styled-content>1 I311V with dietary folate, methionine, vitamin B2<\/jats:sub>, and vitamin B12<\/jats:sub> intake and for MTRR<\/jats:styled-content> I22M<\/jats:styled-content> with dietary folate, a predefined one\u2010carbon dietary pattern, and vitamin B6<\/jats:sub> intake. We observed statistically significant gene\u2010diet interactions with five additional polymorphisms.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Our results provide evidence that FOCM<\/jats:styled-content>\u2010related dietary intakes modify the association between CC<\/jats:styled-content> risk and FOCM<\/jats:styled-content> allelic variants. These findings add to observations showing that folate\u2010related gene\u2010nutrient interactions play an important role in modifying the risk of CC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201200180","type":"journal-article","created":{"date-parts":[[2012,9,7]],"date-time":"2012-09-07T12:30:51Z","timestamp":1347021051000},"page":"721-734","source":"Crossref","is-referenced-by-count":42,"title":["Gene\u2010diet\u2010interactions in folate\u2010mediated one\u2010carbon metabolism modify colon cancer risk"],"prefix":"10.1002","volume":"57","author":[{"given":"Amy Y.","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Epidemiology University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Scherer","sequence":"additional","affiliation":[{"name":"National Center for Tumor Diseases and German Cancer Research Center Division of Preventive Oncology Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Poole","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Harvard School of Public Health Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Potter","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Cancer Prevention Program Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Curtin","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Makar","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Cancer Prevention Program Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha L.","family":"Slattery","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bette J.","family":"Caan","sequence":"additional","affiliation":[{"name":"Department of Research Kaiser Permanente Medical Research Program Oakland CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia M.","family":"Ulrich","sequence":"additional","affiliation":[{"name":"National Center for Tumor Diseases and German Cancer Research Center Division of Preventive Oncology Heidelberg Germany"},{"name":"Fred Hutchinson Cancer Research Center Cancer Prevention Program Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,9,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_7_3_1","volume-title":"Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective","author":"World Cancer Research Fund (WCRF)\/American Institute for Cancer Research","year":"2007"},{"key":"e_1_2_7_4_1","volume-title":"Continuous Update Report: Keeping the Science Current. 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