{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:45:26Z","timestamp":1790279126477,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry of Health","award":["2009-A00533-54"],"award-info":[{"award-number":["2009-A00533-54"]}]},{"name":"Canadian Institutes for Health and Research - Institute of Aging"},{"name":"Servier Institute in France"},{"name":"CIHR-IA, the Drummond Foundation, and the Physician Services Incorporated Foundation of Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2013,2]]},"abstract":"\n Scope<\/jats:title>\n \n Vitamin\n D<\/jats:styled-content>\n deficiency is associated with an enlargement of the lateral cerebral ventricles in rodents. The effect of low serum 25\u2010hydroxyvitamin\n D<\/jats:styled-content>\n (25OHD) on lateral cerebral ventricle volume has not been studied yet in humans. The purpose of this cross\u2010sectional study was to determine whether vitamin\n D<\/jats:styled-content>\n deficiency was associated with greater lateral cerebral ventricle volume in older adults.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n Ninety\u2010two\n C<\/jats:styled-content>\n aucasian community\u2010dwellers with no clinical hydrocephalus (mean, 72.2 \u00b1 6.2 years; 46.7% female) were divided into two groups according to serum 25OHD concentration (deficiency \u2264 50 nmol\/L; normal > 50 nmol\/L). Cerebral ventricular volume was quantified using semi\u2010automated software from three\u2010dimensional\n T<\/jats:styled-content>\n 1\u2010weighted\n MRI<\/jats:styled-content>\n . Age, gender, body mass index, blood pressure, education level, Mini\u2010Mental State Examination, white matter lesions, and serum calcium concentrations were used as covariates. There was an inverse linear association between 25O\n HD<\/jats:styled-content>\n concentration and ventricular volume (\n p<\/jats:italic>\n = 0.049). Compared to individuals with normal 25O\n HD<\/jats:styled-content>\n , those with 25O\n HD<\/jats:styled-content>\n deficiency (\n n<\/jats:italic>\n = 33) had 28% larger lateral ventricles (46.9 \u00b1 26.8 mL versus 36.6 \u00b1 16.4 mL,\n p<\/jats:italic>\n = 0.026). Vitamin\n D<\/jats:styled-content>\n deficiency was associated with an increase in ventricular volume (adjusted\u03b2 = 16.55,\n p<\/jats:italic>\n = 0.023). The ventricular enlargement involved ventricle bodies (\n p<\/jats:italic>\n = 0.025) but not temporal horns (\n p<\/jats:italic>\n = 0.112).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Serum 25O\n HD<\/jats:styled-content>\n deficiency was associated with larger lateral cerebral ventricles. These findings provide a scientific base for vitamin\n D<\/jats:styled-content>\n replacement trials.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mnfr.201200418","type":"journal-article","created":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T17:34:17Z","timestamp":1356111257000},"page":"267-276","source":"Crossref","is-referenced-by-count":65,"title":["Vitamin\n D<\/scp>\n concentration and lateral cerebral ventricle volume in older adults"],"prefix":"10.1002","volume":"57","author":[{"given":"C\u00e9dric","family":"Annweiler","sequence":"first","affiliation":[{"name":"Department of Neuroscience Division of Geriatric Medicine Angers University Hospital, University Memory Clinic of Angers, UPRES EA 4638 University of Angers UNAM Angers France"},{"name":"Department of Medicine Division of Geriatric Medicine Parkwood Hospital St. Joseph's Health Care London; Gait and Brain Lab Lawson Health Research Institute University of Western Ontario London Ontario Canada"},{"name":"Center for Functional and Metabolic Mapping Robarts Research Institute Department of Medical Biophysics Schulich School of Medicine and Dentistry University of Western Ontario London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Montero\u2010Odasso","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Geriatric Medicine Parkwood Hospital St. Joseph's Health Care London; Gait and Brain Lab Lawson Health Research Institute University of Western Ontario London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Hachinski","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences University Hospital University of Western Ontario London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Seshadri","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston University School of Medicine; National Heart Lung, and Blood Institute Framingham MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bartha","sequence":"additional","affiliation":[{"name":"Center for Functional and Metabolic Mapping Robarts Research Institute Department of Medical Biophysics Schulich School of Medicine and Dentistry University of Western Ontario London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Beauchet","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Division of Geriatric Medicine Angers University Hospital, University Memory Clinic of Angers, UPRES EA 4638 University of Angers UNAM Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"e_1_2_7_3_1","first-page":"259","article-title":"Vitamin D in the elderly: 5 points to remember","volume":"9","author":"Annweiler C.","year":"2011","journal-title":"Geriatr. 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