{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:53:00Z","timestamp":1790545980292,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,12,10]],"date-time":"2012-12-10T00:00:00Z","timestamp":1355097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program through the National Research Foundation of Korea"},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"crossref","award":["2011-0003072"],"award-info":[{"award-number":["2011-0003072"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>We examined the effect of paternal folate deficiency on the folate content, the percentage of 5\u2010methycytosine (percentage of 5\u2010m<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>) in the total <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, and the protein expression of insulin\u2010like growth factor\u20102 (<jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20102) in the fetal whole brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Rats were mated after males were fed a folic acid deficient (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) or folic acid supplemented (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>) diet for 4 weeks, and fetuses were killed on day 20 of gestation. The folate content in the fetal liver was significantly lower in the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group than in the <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> group, whereas it did not differ in the fetal whole brain. The percentage of 5\u2010m<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> and the protein expression of <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20102 in the fetal whole brain were both lower in the <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> group than in the <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> group. There were positive correlations between paternal liver and testis folate content and the percentage of 5\u2010m<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20102 expression in the fetal whole brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results on the folate content, the percentage of 5\u2010m<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20102 expression in the fetal whole brain show that paternal folate deficiency at mating can influence fetal brain <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> methylation and <jats:styled-content style=\"fixed-case\">IGF<\/jats:styled-content>\u20102 expression despite an adequate maternal folate status during the gestational period.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201200558","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T09:43:34Z","timestamp":1355305414000},"page":"671-676","source":"Crossref","is-referenced-by-count":38,"title":["Effects of paternal folate deficiency on the expression of insulin\u2010like growth factor\u20102 and global <scp>DNA<\/scp> methylation in the fetal brain"],"prefix":"10.1002","volume":"57","author":[{"given":"Hye Won","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University Seodaemun\u2010Gu  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Nam","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University Seodaemun\u2010Gu  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Jung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University Seodaemun\u2010Gu  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namsoo","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science and Food Management Ewha Womans University Seodaemun\u2010Gu  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1399-0004.2003.00190.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.11.1345"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01528.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.06.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.55.3.451-458.1991"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00221"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/366362a0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146239940200457X"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00449.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31817dd058"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70598-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.04.015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0140-6736(91)90133-A","article-title":"Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. 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