{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:48:37Z","timestamp":1792288117710,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T00:00:00Z","timestamp":1367020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Indole\u20103\u2010carbinol (<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>), a monomer component extracted from leaves and stems of cruciferous vegetables, has inhibitory effects on tumors, obesity, and liver fibrosis, but its effects on the development of cardiac remodeling remain completely unknown. We determined the effects of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> on cardiac remodeling and heart function using an aortic banding (<jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>) mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Male 8\u2010 to10\u2010wk\u2010old wild\u2010type and <jats:styled-content style=\"fixed-case\">5\u2032 adenosine monophosphate\u2010activated protein kinase (AMPK)<\/jats:styled-content>\u2010\u03b12 knockout mice fed with or without <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> were subjected to <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content> or a sham operation and were phenotyped, accordingly. <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> both prevented and reversed cardiac remodeling induced by <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content>, as assessed by heart weight\/body weight, lung weight\/body weight, and heart weight\/tibia length ratios, echocardiographic and hemodynamic parameters, histological analysis, and gene expression of hypertrophic and fibrotic markers. The inhibitory effect of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> on cardiac remodeling was mediated by <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content>\u2010\u03b1 and extracellular signal\u2010regulated kinases 1\/2 (ERK1\/2) signaling. Moreover, <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content>\u2010\u03b12 gene deficiency completely blocked the inhibitory effects of <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> on cardiac remodeling, preventing the improvements in heart weight\/body weight, lung weight\/body weight, heart weight\/tibia length, cardiac function, gene expression of hypertrophic and fibrotic markers, and phosphorylation of mammalian target of rapamycin and <jats:styled-content style=\"fixed-case\">ERK<\/jats:styled-content>1\/2 signaling components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> both prevents and reverses cardiac remodeling by activating <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content>\u2010\u03b1 signaling. <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> is a potential therapeutic drug for heart failure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201300012","type":"journal-article","created":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T16:32:59Z","timestamp":1367080379000},"page":"1680-1687","source":"Crossref","is-referenced-by-count":29,"title":["Indole\u20103\u2010carbinol protects against pressure overload induced cardiac remodeling via activating <scp>AMPK<\/scp>\u2010\u03b1"],"prefix":"10.1002","volume":"57","author":[{"given":"Wei","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Cardiology Renmin Hospital of Wuhan University Wuhan P. 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