{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:28:43Z","timestamp":1791156523858,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T00:00:00Z","timestamp":1376438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Among food allergies, peanut allergy is frequently associated with severe anaphylactic reactions. In the need for safe and effective therapeutic strategies, probiotics may be considered on the basis of their immunomodulatory properties. The aim of the present study was to investigate the immunological mediators involved in the effects of probiotic <jats:styled-content style=\"fixed-case\">VSL<\/jats:styled-content>#3 oral supplementation on <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 inflammation and anaphylaxis in a mouse model of peanut allergy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">VSL<\/jats:styled-content>#3 supplementation to peanut\u2010sensitized mice was effective in ameliorating anaphylaxis and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2\u2010mediated inflammation, by promoting regulatory responses in the jejunum mucosa and in the mesenteric lymph node, as evaluated by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>, real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, histologic, and immunohistochemical analysis. Probiotic\u2010induced <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 mediates its protective effects through the induction of regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells expressing <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3 and\/or latency\u2010associated peptide, as proven by in vivo blockade of <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 in <jats:styled-content style=\"fixed-case\">VSL<\/jats:styled-content>#3\u2010treated mice with a neutralizing monoclonal antibody one day before challenge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2, induced in the gut by <jats:styled-content style=\"fixed-case\">VSL<\/jats:styled-content>#3 supplementation, is capable of reducing the <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>h2 inflammation associated with food anaphylaxis in a mouse model of peanut sensitization. <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 acts through the induction\/maintenance of regulatory <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cells expressing <jats:styled-content style=\"fixed-case\">FOXP<\/jats:styled-content>3 and\/or latency\u2010associated peptide. Probiotics supplementation may represent an effective and safe strategy for treating food allergies in adult population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201300028","type":"journal-article","created":{"date-parts":[[2013,8,14]],"date-time":"2013-08-14T09:56:21Z","timestamp":1376474181000},"page":"2233-2244","source":"Crossref","is-referenced-by-count":40,"title":["Probiotic <scp>VSL<\/scp>#3\u2010induced <scp>TGF<\/scp>\u2010\u03b2 ameliorates food allergy inflammation in a mouse model of peanut sensitization through the induction of regulatory <scp>T<\/scp> cells in the gut mucosa"],"prefix":"10.1002","volume":"57","author":[{"given":"Bianca","family":"Barletta","sequence":"first","affiliation":[{"name":"Department of Infectious Parasitic and Immune\u2010mediated Diseases Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Science University of Camerino Matelica (MC) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Schiavi","sequence":"additional","affiliation":[{"name":"Department of Infectious Parasitic and Immune\u2010mediated Diseases Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Butteroni","sequence":"additional","affiliation":[{"name":"Department of Infectious Parasitic and Immune\u2010mediated Diseases Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Corinti","sequence":"additional","affiliation":[{"name":"Department of Infectious Parasitic and Immune\u2010mediated Diseases Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Boirivant","sequence":"additional","affiliation":[{"name":"Department of Infectious Parasitic and Immune\u2010mediated Diseases Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Di Felice","sequence":"additional","affiliation":[{"name":"Department of Infectious Parasitic and Immune\u2010mediated Diseases Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45434"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.042407.205711"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-007-0018-y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01688.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.029"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.05.015"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2653"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02783.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195568"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2850"},{"key":"e_1_2_7_13_1","unstructured":"Joint FAO\/WHO Working Group Report on Drafting Guidelines for the Evaluation of Probiotics in Food. 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