{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T20:40:40Z","timestamp":1776112840502,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Glycation of allergens via Maillard reaction or chemical conjugation has been shown to influence susceptibility to food\u2010induced allergies. It is hypothesized that mucosal immune response bias can be favorably altered by orally administering various forms of glycated ovalbumin (OVA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Groups of Balb\/c mice (<jats:italic>n<\/jats:italic> = 10) were orally sensitized to OVA and administered various forms of glycated OVA (glucose, mannose, glucomannan, galactomannan, and a mixture containing OVA and glucomannan). Outcomes post oral challenge were measured as clinical allergic signs, serum histamine, mouse mast cell protease 1 (MMCP\u20101), antibody activity, type\u20101\/2 cytokines, percentage of T\u2010regulatory cells (T\u2010regs) and in vitro dendritic cell, and T\u2010cell\u2010related mechanisms. Clinical signs and specific IgE were decreased (<jats:italic>p<\/jats:italic> \u2264 0.05), and T\u2010reg cell percentage was increased in the mannose and glucomannan treated groups. The OVA\u2010mannose group also had less histamine, MMCP\u20101, specific IgG, IL\u20104 and IL\u201017, and more IL\u201012p70 (<jats:italic>p<\/jats:italic> \u2264 0.05). Other parameters measured did not differ significantly among groups. Also, OVA\u2010glycated mannose reduced maturation and uptake by dendritic cells. Less activation of T cells and type\u20102 cytokine response in DC\u2013T\u2010cell cocultures were observed with OVA\u2010glycated mannose stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study validates, for the first time, the use of OVA\u2010glycated mannose and glucomannan for potential beneficial dietary interventions for allergy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201300067","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T01:52:01Z","timestamp":1381542721000},"page":"405-417","source":"Crossref","is-referenced-by-count":46,"title":["Effects of ovalbumin glycoconjugates on alleviation of orally induced egg allergy in mice via dendritic\u2010cell maturation and T\u2010cell activation"],"prefix":"10.1002","volume":"58","author":[{"given":"Prithy","family":"Rupa","sequence":"first","affiliation":[{"name":"Department of Food Science Ontario Agricultural College, University of Guelph  Guelph Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Food Biotechnology Laboratory Graduate School of Agricultural Science, Shinshu University  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Katayama","sequence":"additional","affiliation":[{"name":"Food Biotechnology Laboratory Graduate School of Agricultural Science, Shinshu University  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Mine","sequence":"additional","affiliation":[{"name":"Department of Food Science Ontario Agricultural College, University of Guelph  Guelph Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.05.048"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.S3.1631"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.040"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00201.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1370"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/oxfordjournals.jbchem.a123766","article-title":"Carbohydrate binding specificities of monoclonal antibodies raised against lactose\u2010protein Maillard adducts","volume":"111","author":"Matsuda T.","year":"1992","journal-title":"J. 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