{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:03:49Z","timestamp":1777622629397,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T00:00:00Z","timestamp":1383091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Dietary fish oil (FO) and soy protein (SP) are two interventions that slow disease progression in the Han:SPRD\u2010<jats:italic>Cy<\/jats:italic>rat model of polycystic kidney disease (PKD). Inhibition of cyclooxygenase (COX)\u2010derived eicosanoids also reduces disease progression, but the role of lipoxygenase (LOX) products in this disease is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Since dietary FO and SP have been shown to alter eicosanoid formation via differing mechanisms, Han:SPRD\u2010<jats:italic>Cy<\/jats:italic>rats were given diets containing either casein protein (CP) or SP, and soy oil (SO) or FO. Analysis of eicosanoids revealed that renal COX products were higher and LOX products were lower in diseased kidneys. SP feeding resulted in lower COX products, activity and COX1 protein and higher LOX products in the diseased kidneys in parallel with reduced renal cyst growth and fibrosis. By comparison, FO reduced both COX and LOX products produced from<jats:italic>n<\/jats:italic>\u20106 fatty acids and increased 3\u2010series prostanoids in both normal and diseased cortex and medulla, but these differences did not parallel effects on disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Renal COX\u2010derived eicosanoids are elevated and LOX products are reduced in this model of kidney disease. The effects of dietary SP, but not FO, on renal eicosanoids parallel the effects on disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201300332","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T08:55:57Z","timestamp":1383123357000},"page":"768-781","source":"Crossref","is-referenced-by-count":17,"title":["Renal cyclooxygenase and lipoxygenase products are altered in polycystic kidneys and by dietary soy protein and fish oil treatment in the Han:SPRD\u2010<i>Cy<\/i>rat"],"prefix":"10.1002","volume":"58","author":[{"given":"Naser H. M.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Department of Human Nutritional Sciences University of Manitoba Winnipeg Manitoba Canada"},{"name":"Canadian Centre for Agri\u2010Food Research in Health and Medicine St. Boniface Hospital Research Centre Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Human Nutritional Sciences University of Manitoba Winnipeg Manitoba Canada"},{"name":"Canadian Centre for Agri\u2010Food Research in Health and Medicine St. Boniface Hospital Research Centre Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessay G.","family":"Devassy","sequence":"additional","affiliation":[{"name":"Department of Human Nutritional Sciences University of Manitoba Winnipeg Manitoba Canada"},{"name":"Canadian Centre for Agri\u2010Food Research in Health and Medicine St. Boniface Hospital Research Centre Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamio","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Human Nutritional Sciences University of Manitoba Winnipeg Manitoba Canada"},{"name":"Canadian Centre for Agri\u2010Food Research in Health and Medicine St. Boniface Hospital Research Centre Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold M.","family":"Aukema","sequence":"additional","affiliation":[{"name":"Department of Human Nutritional Sciences University of Manitoba Winnipeg Manitoba Canada"},{"name":"Canadian Centre for Agri\u2010Food Research in Health and Medicine St. Boniface Hospital Research Centre Winnipeg Manitoba Canada"},{"name":"Manitoba Institute of Child Health, Manitoba Winnipeg Manitoba Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R900004-JLR200"},{"key":"e_1_2_7_3_1","first-page":"5","article-title":"Eicosanoids: generation and detection in mammalian cells","volume":"462","author":"O'Donnell V. B.","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.6.F965"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00443.2002"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.70.113006.100614"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1681\/ASN.V1351261","article-title":"Selective cyclooxygenase\u20102 inhibition impairs glomerular capillary healing in experimental glomerulonephritis","volume":"13","author":"Kitahara M.","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0460fje"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00257.2006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3181\/0811-RM-315"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00332.2005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-1611-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90705.2008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061328"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512004606"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-213-44031"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512001559"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.1.180"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.157883"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507250470"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00835.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00465.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V102300"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9428452"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1139\/Y09-110"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf300598a"},{"key":"e_1_2_7_27_1","first-page":"S","article-title":"Effects of acute protein loads of different sources on glomerular filtration rate","volume":"32","author":"Dhaene M.","year":"1987","journal-title":"Kidney Int."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.178"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046311"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2007.01.002"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"F711","DOI":"10.1152\/ajprenal.1989.256.4.F711","article-title":"Dietary protein intake modulates glomerular eicosanoid production in the rat","volume":"256","author":"Don B. R.","year":"1989","journal-title":"Am. J. Physiol. Renal Fluid Electrol. Physiol"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"F1088","DOI":"10.1152\/ajprenal.1987.252.6.F1088","article-title":"High protein intake stimulates glomerular prostaglandin formation in remnant kidneys","volume":"252","author":"Stahl R. A. K.","year":"1987","journal-title":"Am. J. Physiol. Renal Fluid Electrol. Physiol"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005060601"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.11.1939"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-002-1001-4"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(07)32003-X"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1044-0305(98)00013-0"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-004-1221-7"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.02.036"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.253"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000174259"},{"key":"e_1_2_7_43_1","first-page":"F377","article-title":"Segmental synthesis and actions of prostaglandins along the nephron","volume":"253","author":"Bonvalet J. P.","year":"1987","journal-title":"Am. J. Physiol."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2011.04.004"},{"key":"e_1_2_7_45_1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0022-3565(25)39423-1","article-title":"Differential vasoconstrictor potencies of free fatty acids in the lung vasculature: 2\u2010versus 3\u2010series prostanoid generation","volume":"267","author":"Grimminger F.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(86)90217-0"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0265"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209789271834"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/09637480701592897"},{"key":"e_1_2_7_50_1","first-page":"F659","article-title":"Prostaglandins stimulate renin secretion and renin mRNA in mouse renal juxtaglomerular cells","volume":"271","author":"Jensen B. L.","year":"1996","journal-title":"Am. J. Physiol."},{"key":"e_1_2_7_51_1","first-page":"290","article-title":"Effect of selective inhibition of the inducible cyclooxygenase on renin release in healthy volunteers","volume":"46","author":"Stichtenoth D. O.","year":"1998","journal-title":"J. Investig. Med."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.16.8.1071"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)43209-2"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02529883"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32831a9df7"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00931.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002629"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007070771"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201300332","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201300332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T18:57:38Z","timestamp":1746039458000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201300332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,30]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1002\/mnfr.201300332"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201300332","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,30]]}}}