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Thus, a network approach is becoming feasible, describing the interaction of a single polyphenol with cellular networks. Here we have selected icariin to draw a prototypic network of icariin activities. Icariin appears to be a promising drug to treat major age\u2010related diseases, like neurodegeneration, memory and depressive disorders, chronic inflammation, diabetes, and osteoporosis. It interacts with several relevant pathways, like<jats:italic>PDE<\/jats:italic>,<jats:italic>TGF\u2010\u00df<\/jats:italic>,<jats:italic>MAPK<\/jats:italic>,<jats:italic>PPAR<\/jats:italic>,<jats:italic>NOS<\/jats:italic>,<jats:italic>IGF<\/jats:italic>,<jats:italic>Sirtuin<\/jats:italic>, and others. Such networks will be useful to future comparative studies of complex effects of polyphenols.<\/jats:p>","DOI":"10.1002\/mnfr.201300409","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T17:41:15Z","timestamp":1386265275000},"page":"49-60","source":"Crossref","is-referenced-by-count":32,"title":["Plant polyphenols in the treatment of age\u2010associated diseases: Revealing the pleiotropic effects of icariin by network analysis"],"prefix":"10.1002","volume":"58","author":[{"given":"Jan Kevin","family":"Schluesener","sequence":"first","affiliation":[{"name":"Division of Immunopathology of the Nervous System Department of Neuropathology Institute of Pathology and Neuropathology University of Tuebingen Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Schluesener","sequence":"additional","affiliation":[{"name":"Division of Immunopathology of the Nervous System Department of Neuropathology Institute of Pathology and Neuropathology University of Tuebingen Tuebingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2012.01.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2011-101803"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328342741c"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710792231950"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1536"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046524"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1104"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn3000907"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1943-3"},{"key":"e_1_2_7_11_1","first-page":"15","article-title":"Effects of icariin on cGMP\u2010specific PDE5 and cAMP\u2010specific PDE4 activities","volume":"5","author":"Xin Z. 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