{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:17:41Z","timestamp":1789787861281,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T00:00:00Z","timestamp":1387324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BBSRC Institute Strategic Programme"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2014,5]]},"abstract":"Scope<\/jats:title>The human\/microbiota cross\u2010talk is partially mediated by bacteria\u2010derived peptides like Serine\u2010Threonine peptide (ST<\/jats:styled-content>p), which is resistant to gut proteolysis, is found in the human healthy colon and induces regulatory properties on gut dendritic cells (DC<\/jats:styled-content>s); here we characterized human gut DC<\/jats:styled-content> in ulcerative colitis (UC<\/jats:styled-content>) patients and studied the effect of STp<\/jats:styled-content> on their properties.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>Human colonic DC<\/jats:styled-content> from healthy controls and UC<\/jats:styled-content> patients were isolated, conditioned for 24 h +\/\u2212 ST<\/jats:styled-content>p and characterized by flow cytometry, immunohistochemistry, and electron microscopy. Expression of immature DC<\/jats:styled-content> markers DC<\/jats:styled-content>\u2010SIGN<\/jats:styled-content> and ILT<\/jats:styled-content>3, and T<\/jats:styled-content>oll\u2010like receptors were increased on gut UC<\/jats:styled-content>\u2010DC<\/jats:styled-content>. Langerin (involved in phagocytosis), lymph node homing marker CCR<\/jats:styled-content>7, and activation markers CD<\/jats:styled-content>40\/CD<\/jats:styled-content>80\/CD<\/jats:styled-content>86 were decreased in UC<\/jats:styled-content>. Gut DC<\/jats:styled-content> had restricted stimulatory capacity for T<\/jats:styled-content>\u2010cells in UC<\/jats:styled-content>. Conditioning of DC<\/jats:styled-content> with ST<\/jats:styled-content>p in vitro reduced T<\/jats:styled-content>oll\u2010like receptor expression, increased CD<\/jats:styled-content>40 and CD<\/jats:styled-content>80 expression, and restored their stimulatory capacity.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Colonic DC<\/jats:styled-content>s display an abnormal immature phenotype in UC<\/jats:styled-content>, which was partially restored following ST<\/jats:styled-content>p treatment. Bacteria\u2010derived metabolites, like ST<\/jats:styled-content>p, seem to have a role in gut homeostasis that is missing in UC<\/jats:styled-content> so they might lead a new era of probiotic products setting the basis for nondrug dietary therapy in inflammatory bowel disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201300596","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T10:03:09Z","timestamp":1387360989000},"page":"1132-1143","source":"Crossref","is-referenced-by-count":66,"title":["Altered human gut dendritic cell properties in ulcerative colitis are reversed by Lactobacillus plantarum<\/i> extracellular encrypted peptide STp"],"prefix":"10.1002","volume":"58","author":[{"given":"Hafid O.","family":"Al\u2010Hassi","sequence":"first","affiliation":[{"name":"Antigen Presentation Research Group Imperial College London Northwick Park and St. Mark's Campus Harrow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth 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