{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:01:43Z","timestamp":1766048503001,"version":"3.37.3"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T00:00:00Z","timestamp":1406505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-86727"],"award-info":[{"award-number":["MOP-86727"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["HEALTH-F2-2009-223175"],"award-info":[{"award-number":["HEALTH-F2-2009-223175"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001282","name":"Ovarian Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001282","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U19-CA148112"],"award-info":[{"award-number":["U19-CA148112"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["CRTG-00-196-01-CCE"],"award-info":[{"award-number":["CRTG-00-196-01-CCE"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C490\/A6187, C490\/A10119, C490\/A10124, C536\/A13086, C536\/A6689"],"award-info":[{"award-number":["C490\/A6187, C490\/A10119, C490\/A10124, C536\/A13086, C536\/A6689"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Scope<\/jats:title>We reevaluated previously reported associations between variants in pathways of one\u2010carbon (1\u2010C) (folate) transfer genes and ovarian carcinoma (OC) risk, and in related pathways of purine and pyrimidine metabolism, and assessed interactions with folate intake.<\/jats:p><\/jats:sec>Methods and results<\/jats:title>Odds ratios (OR) for 446 genetic variants were estimated among 13\u00a0410 OC cases and 22\u00a0635 controls, and among 2281 cases and 3444 controls with folate information. Following multiple testing correction, the most significant main effect associations were for dihydropyrimidine dehydrogenase (DPYD<\/jats:italic>) variants rs11587873 (OR = 0.92; p<\/jats:italic> = 6 \u00d7 10\u22125<\/jats:sup>) and rs828054 (OR = 1.06; p<\/jats:italic> = 1 \u00d7 10\u22124<\/jats:sup>). Thirteen variants in the pyrimidine metabolism genes, DPYD<\/jats:italic>, DPYS<\/jats:italic>, PPAT<\/jats:italic>, and TYMS<\/jats:italic>, also interacted significantly with folate in a multivariant analysis (corrected p<\/jats:italic> = 9.9 \u00d7 10\u22126<\/jats:sup>) but collectively explained only 0.2% of OC risk. Although no other associations were significant after multiple testing correction, variants in SHMT1<\/jats:italic> in 1\u2010C transfer, previously reported with OC, suggested lower risk at higher folate (p<\/jats:italic>interaction<\/jats:sub> = 0.03\u20130.006).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Variation in pyrimidine metabolism genes, particularly DPYD<\/jats:italic>, which was previously reported to be associated with OC, may influence risk; however, stratification by folate intake is unlikely to modify disease risk appreciably in these women. SHMT1<\/jats:italic> SNP\u2010by\u2010folate interactions are plausible but require further validation. Polymorphisms in selected genes in purine metabolism were not associated with OC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400068","type":"journal-article","created":{"date-parts":[[2014,7,28]],"date-time":"2014-07-28T06:20:15Z","timestamp":1406528415000},"page":"2023-2035","source":"Crossref","is-referenced-by-count":8,"title":["Consortium analysis of gene and gene\u2013folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk"],"prefix":"10.1002","volume":"58","author":[{"given":"Linda E.","family":"Kelemen","sequence":"first","affiliation":[{"name":"Departments of Medical Genetics and Oncology University of Calgary Calgary AB Canada*"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn L.","family":"Terry","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Epidemology Center Brigham and Women's Hospital Boston MA USA"},{"name":"Department of Epidemiology Harvard School of Public Health Boston MA 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