{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:18:20Z","timestamp":1790169500938,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T00:00:00Z","timestamp":1404086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CIBER de Enfermedades Respiratorias"},{"name":"Carlos III Institute of Health initiative"},{"DOI":"10.13039\/501100012006","name":"Conchita R\u00e1bago Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012006","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Shrimp is a seafood consumed worldwide and the main cause of severe allergenic reactions to crustaceans. Seafood allergy has been related to mite sensitization, mainly mediated by tropomyosin, but other proteins could be involved. The aim of the study was to identify new shrimp allergens implicated in mite\u2010seafood cross\u2010reactivity (CR) in two different climate populations: dry and humid climates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Shrimp and mite IgE\u2010binding profiles of patients from continental dry and humid climates were analyzed by immunoblotting, and the most frequently recognized <jats:italic>Solenocera melantho<\/jats:italic> shrimp proteins were identified by MS as \u03b1\u2010actinin, \u03b2\u2010actin, fructose biphosphate aldolase, arginine kinase, sarcoplasmic calcium\u2010binding protein, and ubiquitin. Using inhibition immunoblot assays, we demonstrate that tropomyosin and ubiquitin were responsible for mite\u2010seafood CR from both climates; but also \u03b1\u2010actinin and arginine kinase are implicated in dry\u2010 and humid\u2010climate populations, respectively. Reciprocal inhibition assays demonstrated that mites are the primary sensitizer in humid\u2010climate, as shrimp is in continental dry\u2010climate population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several new shrimp allergens have been identified and should be considered in the diagnosis and treatment of shrimp allergy and mite\u2010seafood CR. Differences in mite\u2010seafood CR were founded to be based on the climate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400122","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T01:10:16Z","timestamp":1404177016000},"page":"1915-1925","source":"Crossref","is-referenced-by-count":66,"title":["New shrimp IgE\u2010binding proteins involved in mite\u2010seafood cross\u2010reactivity"],"prefix":"10.1002","volume":"58","author":[{"given":"Cristina","family":"G\u00e1mez","sequence":"first","affiliation":[{"name":"Department of Immunology IIS\u2010Fundaci\u00f3n Jim\u00e9nez D\u00edaz  Madrid Spain"},{"name":"CIBER de Enfermedades Respiratorias (CIBERES)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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