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After studying the in vitro colonic metabolism pathways of the individual phenols, the presence of their colonic metabolites was investigated in human faecal samples obtained before and after the sustained intake (3 weeks) of a daily dose of 25 mL of a phenol\u2010enriched olive oil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>The in vitro colon fermentation of the four individual phenolic compounds revealed (i) an increase in phenolic acids, (ii) the stability of hydroxytyrosol and tyrosol and (iii) the high degradation of hydroxytyrosol acetate and oleuropein. Additionally, a moderate intake of a phenol\u2010rich olive oil raised the concentration in human faeces of free hydroxytyrosol and phenylacetic and phenylpropionic acids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The products of colonic catabolism of olive oil phenolic compounds could be good candidates for novel preventive strategies and open a promising line of research into the preventive action of olive oil phenols in colon and other bowel diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400124","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T15:51:29Z","timestamp":1404316289000},"page":"1809-1819","source":"Crossref","is-referenced-by-count":95,"title":["Faecal microbial metabolism of olive oil phenolic compounds: In vitro and in vivo approaches"],"prefix":"10.1002","volume":"58","author":[{"given":"Juana I.","family":"Mosele","sequence":"first","affiliation":[{"name":"Food Technology Department, UTPV\u2010XaRTA, Agrotecnio Center University of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Mart\u00edn\u2010Pel\u00e1ez","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk and Nutrition Research Group Inflammatory and Cardiovascular Disorders Research Program Hospital del Mar Medical Research Institute (IMIM) Barcelona Biomedical Research Park (PRBB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Maci\u00e0","sequence":"additional","affiliation":[{"name":"Food Technology Department, UTPV\u2010XaRTA, Agrotecnio Center University of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Farr\u00e0s","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk and Nutrition Research Group Inflammatory and Cardiovascular Disorders Research Program Hospital del Mar Medical Research Institute (IMIM) Barcelona Biomedical Research Park (PRBB)  Barcelona Spain"},{"name":"Ph.D. Program in Biochemistry, Molecular Biology and Biomedicine Department of Biochemistry and Molecular Biology Universitat Aut\u00f2noma de Barcelona (UAB)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa\u2010Maria","family":"Valls","sequence":"additional","affiliation":[{"name":"Lipid and Arteriosclerosis Research Unit, CIBERDEM St. Joan de Reus University Hospital, IISPV, Faculty of Medicine and Health Sciences Universitat Rovira i Virgili  Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00darsula","family":"Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Lipid and Arteriosclerosis Research Unit, CIBERDEM St. Joan de Reus University Hospital, IISPV, Faculty of Medicine and Health Sciences Universitat Rovira i Virgili  Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Jos\u00e9","family":"Motilva","sequence":"additional","affiliation":[{"name":"Food Technology Department, UTPV\u2010XaRTA, Agrotecnio Center University of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,2]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Food Balance Sheet Food and Agriculture Organization of the United Nations (FAOSTAT). 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