{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:36:27Z","timestamp":1767904587399,"version":"3.49.0"},"reference-count":224,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T00:00:00Z","timestamp":1404086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondazione Cassa di Risparmio di Fabriano e Cupramontana"},{"name":"Italian Ministry of the University and Research","award":["PRIN 2010-2011"],"award-info":[{"award-number":["PRIN 2010-2011"]}]},{"name":"Italian Ministry of the University and Research","award":["20102CHST5_007"],"award-info":[{"award-number":["20102CHST5_007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:p>Uterine leiomyomas (fibroids, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70\u201380% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pressure on the bladder, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 6 billion dollars annually in the United States. Unfortunately, no long\u2010term medical treatments are available. Dysregulation of inflammatory processes are thought to be involved in the initiation of leiomyoma and extracellular matrix deposition, cell proliferation, and angiogenesis are the key cellular events implicated in leiomyoma growth. In modern pharmaceutical industries, dietary phytochemicals are used as source of new potential drugs for many kinds of tumors. Dietary phytochemicals may exert therapeutic effects by interfering with key cellular events of the tumorigenesis process. At present, a negligible number of phytochemicals have been tested as therapeutic agents against fibroids. In this context, our aim was to introduce some of the potential dietary phytochemicals that have shown anti\u2010inflammatory, antiproliferative, antifibrotic, and antiangiogenic activities in different biological systems. This review could be useful to stimulate the evaluation of these phytochemicals as possible therapies for uterine fibroids.<\/jats:p>","DOI":"10.1002\/mnfr.201400134","type":"journal-article","created":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T08:09:31Z","timestamp":1404115771000},"page":"1667-1684","source":"Crossref","is-referenced-by-count":47,"title":["Use of dietary phytochemicals to target inflammation, fibrosis, proliferation, and angiogenesis in uterine tissues: Promising options for prevention and treatment of uterine fibroids?"],"prefix":"10.1002","volume":"58","author":[{"given":"Md Soriful","family":"Islam","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Faculty of Medicine Polytechnic University of Marche Ancona Italy"},{"name":"Biotechnology and Microbiology Laboratory Department of Botany University of Rajshahi Rajshahi Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Most Mauluda","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences Faculty of Medicine Polytechnic University of Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Ciavattini","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Polytechnic University of Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano Raffaele","family":"Giannubilo","sequence":"additional","affiliation":[{"name":"Department of Clinical Science Polytechnic University of Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Protic","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Faculty of Medicine Polytechnic University of Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milijana","family":"Janjusevic","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Faculty of Medicine Polytechnic University of Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Domenico","family":"Procopio","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Sciences Faculty of Medicine Polytechnic University of Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Segars","sequence":"additional","affiliation":[{"name":"Program in Reproductive and Adult Endocrinology Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health Bethesda MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Castellucci","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Faculty of Medicine Polytechnic University of Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4400-3786","authenticated-orcid":false,"given":"Pasquapina","family":"Ciarmela","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, Faculty of Medicine Polytechnic University of Marche Ancona Italy"},{"name":"Department of Information Engineering Polytechnic University of Marche Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr031"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112063"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3237"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00534-6"},{"key":"e_1_2_8_7_1","first-page":"483","article-title":"Uterine leiomyomas. Racial differences in severity, symptoms and age at diagnosis","volume":"41","author":"Kjerulff K. H.","year":"1996","journal-title":"J. Reprod. Med."},{"key":"e_1_2_8_8_1","first-page":"90","article-title":"Association of race, age and body mass index with gross pathology of uterine fibroids","volume":"53","author":"Moore A. B.","year":"2008","journal-title":"J. Reprod. Med."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808188105"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.whi.2009.03.001"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03622-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200202000-00012"},{"issue":"211","key":"e_1_2_8_13_1","first-page":"e211","article-title":"The estimated annual cost of uterine leiomyomata in the United States","volume":"206","author":"Cardozo E. R.","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70666-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2010.05.012"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.04.046"},{"key":"e_1_2_8_17_1","first-page":"1","volume-title":"Understanding Uterine Fibroids\u2014Fibroids","author":"Leppert P.","year":"2013"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1251476"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2005.12.001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90077-2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.11.4092"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.03.007"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)61022-1"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90092-0"},{"key":"e_1_2_8_25_1","first-page":"104","article-title":"The prevention of bone loss in young women treated with GnRH analogues with \u201cadd\u2010back\u201d estrogen therapy","volume":"81","author":"Leather A. T.","year":"1993","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_8_26_1","first-page":"720","article-title":"Treatment of leiomyomata uteri with leuprolide acetate depot: a double\u2010blind, placebo\u2010controlled, multicenter study. The Leuprolide Study Group","volume":"77","author":"Friedman A. J.","year":"1991","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00102-W"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31818aa930"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.094"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103180"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103182"},{"key":"e_1_2_8_32_1","first-page":"17","article-title":"Effects of a new progesterone receptor modulator, CDB\u20104124, on fibroid size and uterine bleeding","volume":"3","author":"Wiehle R. D.","year":"2008","journal-title":"US Obstet. Gynecol."},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/np200906s"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-2"},{"key":"e_1_2_8_35_1","first-page":"CD005292","article-title":"Herbal preparations for uterine fibroids","volume":"4","author":"Liu J. P.","year":"2009","journal-title":"Cochrane Database Syst. Rev"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.08.065"},{"key":"e_1_2_8_37_1","first-page":"477","article-title":"Treatment of symptomatic uterine fibroids with green tea extract: a pilot randomized controlled clinical study","volume":"5","author":"Roshdy E.","year":"2013","journal-title":"Int. J. Women's Health"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.03.045"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719107312681"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.056"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.08.049"},{"key":"e_1_2_8_42_1","first-page":"134","volume-title":"Counseling the Patient with Uterine Fibroids\u2014Fibroids","author":"Christman G. M.","year":"2012"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.6.2533"},{"key":"e_1_2_8_44_1","first-page":"295","article-title":"Interleukin\u20106\u2010174G\/C polymorphism in breast cancer and uterine leiomyoma patients: a population\u2010based case control study","volume":"29","author":"Litovkin K. V.","year":"2007","journal-title":"Exp. Oncol."},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1377"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.5.7469"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.11.4138"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det238"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(98)00072-7"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.111160"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-008-0038-1"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1071-5576(02)00191-0"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.6.2226"},{"key":"e_1_2_8_54_1","first-page":"602","article-title":"Histological and biochemical studies of collagen in human uterine leiomyomas","volume":"60","author":"Fujita M.","year":"1985","journal-title":"Hokkaido Igaku Zasshi"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.04.030"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00418-0"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.3.900"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719109343310"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.11.057"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2011.09.001"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.01.081"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2623"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.5.1.2234"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(89)80046-8"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.01.034"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.118"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114522552"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.108.075887"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-013-0029-7"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111408111"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-653"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0206-171"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2868"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.01.005"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt042"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114542019"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.07.093"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.10.885"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2007.11.009"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-12"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2010.507287"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-09-0049"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.1997.3.7"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem185"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den087"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2012.44.4.024"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635580903285163"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986706776360987"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican0385-114"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976837"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.03.011"},{"key":"e_1_2_8_92_1","first-page":"171573","article-title":"Allicin attenuates inflammation and suppresses HLA\u2010B27 protein expression in ankylosing spondylitis mice","volume":"2013","author":"Gu X.","year":"2013","journal-title":"J. Biomed. Biotechnol."},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2009.11.001"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-012-6415-z"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2012.04.007"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2003.11.059"},{"key":"e_1_2_8_97_1","first-page":"1585","article-title":"Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways","volume":"24","author":"Zhang W.","year":"2010","journal-title":"Oncol. Rep."},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2010.550894"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2010.509837"},{"key":"e_1_2_8_100_1","first-page":"41","article-title":"Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK\u2010dependent pathway","volume":"28","author":"Cha J. H.","year":"2012","journal-title":"Oncol. Rep."},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC382_14"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635580701733083"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4514.2005.00031.x"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-6-33"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2010.00565.x"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509992935"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.09.030"},{"key":"e_1_2_8_108_1","first-page":"363","article-title":"Inhibition of liver fibrosis by ellagic acid","volume":"40","author":"Thresiamma K. C.","year":"1996","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01493-X"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.06.008"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0423-7"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.04.004"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00323-1"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2013.832779"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/306705"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2004.06.004"},{"key":"e_1_2_8_117_1","first-page":"1829","article-title":"Ellagic acid, a dietary polyphenol, selectively cytotoxic to HSC\u20102 oral carcinoma cells","volume":"33","author":"Weisburg J. H.","year":"2013","journal-title":"Anticancer Res."},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.06.025"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgi024"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-1977-9"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.4.9.1993"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-12-4589"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfr249"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42790"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/293642"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.03.040"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.10.057"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.02.002"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.07.008"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11844"},{"key":"e_1_2_8_131_1","first-page":"1391","article-title":"Indole\u20103\u2010carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane\u2010induced rat colon carcinogenesis","volume":"27","author":"Suzui M.","year":"2005","journal-title":"Int. J. Oncol."},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.12.028"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050034w"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.112359"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.02.185"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140714620"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100623"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019652"},{"key":"e_1_2_8_139_1","first-page":"681","article-title":"Lycopene protects against LPS\u2010induced proinflammatory cytokine cascade in HUVECs","volume":"68","author":"Wang Y.","year":"2013","journal-title":"Pharmazie"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2007.12.008"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.07.011"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(01)00132-2"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152812798889376"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC3601_14"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.03.017"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.5520230302"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204452"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq157"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507746883"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511005800"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100683"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000308"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00032a015"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf000892m"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2005.02.047"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2012.661513"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2013.2912"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2013.04.019"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9473-2"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026261"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29807"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1211\/0022357021396"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2010.05.019"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp245"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2010-0338OC"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07262.x"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2012-0432"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05174.x"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2003.08.008"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022869716643"},{"key":"e_1_2_8_171_1","first-page":"821","article-title":"Inhibition of ErbB\u20102 and ErbB\u20103 expression by quercetin prevents transforming growth factor alpha (TGF\u2010\u00ce\u00b1)\u2010and epidermal growth factor (EGF)\u2010induced human PC\u20103 prostate cancer cell proliferation","volume":"23","author":"Huynh H.","year":"2003","journal-title":"Int. J. Oncol."},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.4162\/nrp.2013.7.6.439"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.105.005280"},{"key":"e_1_2_8_174_1","first-page":"837","article-title":"Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin","volume":"19","author":"Choi J.\u2010A.","year":"2001","journal-title":"Int. J. Oncol."},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf101510z"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.11.008"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1179\/1607845412Y.0000000042"},{"key":"e_1_2_8_178_1","first-page":"2829","article-title":"Quercetin mediated reduction of angiogenic markers and chaperones in DLA\u2010induced solid tumours","volume":"12","author":"Anand K.","year":"2011","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.10.069"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047516"},{"key":"e_1_2_8_181_1","first-page":"25","article-title":"Effects of quercetin on morphology and VEGF secretion of leukemia cells NB4 in vitro]","volume":"28","author":"Zhong L.","year":"2006","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635580802100851"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/419891"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.6.2399"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC421_1"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104794200"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.07.036"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0641-0"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042989"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.01.008"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4240"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2013.06.003"},{"key":"e_1_2_8_193_1","first-page":"3381","article-title":"Autophagy inhibition enhances sulforaphane\u2010induced apoptosis in human breast cancer cells","volume":"30","author":"Kanematsu S.","year":"2010","journal-title":"Anticancer Res."},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000547"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2011.05.015"},{"key":"e_1_2_8_196_1","first-page":"134","article-title":"Effects of phytochemicals sulforaphane on uridine diphosphate\u2010glucuronosyltransferase expression as well as cell\u2010cycle arrest and apoptosis in human colon cancer Caco\u20102 cells","volume":"55","author":"Wang M.","year":"2012","journal-title":"Chin. J. Physiol."},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.11.034"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0324"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2006.06.015"},{"key":"e_1_2_8_200_1","first-page":"1473","article-title":"Sulforaphane inhibits angiogenesis through activation of FOXO transcription factors","volume":"22","author":"Davis R.","year":"2009","journal-title":"Oncol. Rep."},{"key":"e_1_2_8_201_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031318"},{"key":"e_1_2_8_202_1","first-page":"4375","article-title":"Ursolic acid inhibits nuclear factor\u2010kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down\u2010regulation of cyclooxygenase 2, matrix metalloproteinase","volume":"63","author":"Shishodia S.","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_8_203_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhq002"},{"key":"e_1_2_8_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2011.03.010"},{"key":"e_1_2_8_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.11.033"},{"key":"e_1_2_8_206_1","first-page":"353","article-title":"[Study on the effect of ursolic acid (UA) on the myocardial fibrosis of experimental diabetic mice]","volume":"29","author":"Yang J. J.","year":"2013","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.10.040"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.11.019"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063872"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-009-0618-y"},{"key":"e_1_2_8_211_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20610"},{"key":"e_1_2_8_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.04.027"},{"key":"e_1_2_8_213_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/419343"},{"key":"e_1_2_8_214_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00726.x"},{"key":"e_1_2_8_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.03.031"},{"key":"e_1_2_8_216_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1364"},{"key":"e_1_2_8_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.05.183"},{"key":"e_1_2_8_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.09.004"},{"key":"e_1_2_8_219_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.2101"},{"key":"e_1_2_8_220_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534735410367647"},{"key":"e_1_2_8_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00305-1"},{"key":"e_1_2_8_222_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.016600"},{"key":"e_1_2_8_223_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.108.046201"},{"key":"e_1_2_8_224_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0022-3565(24)37858-9","article-title":"A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5\u2010fluorouracil prodrugs","volume":"287","author":"Okuda H.","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_8_225_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-010-9235-2"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201400134","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201400134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201400134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T14:47:48Z","timestamp":1746283668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201400134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,30]]},"references-count":224,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1002\/mnfr.201400134"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201400134","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,30]]}}}