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The aim of this study was to investigate the effects of <jats:italic>n<\/jats:italic>\u20103 fatty acid (FA) and polyphenol rich diets on plasma and HDL fraction lipidomic profiles in subjects at high cardiovascular risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Ultra performance LC coupled to quadrupole TOF\/MS mass spectrometry global lipidomic profiling was applied to plasma and HDL fraction from an 8 wk randomized intervention with four isoenergetic diets, differing in their natural <jats:italic>n<\/jats:italic>\u20103 FA and polyphenols content, in 78 subjects with a high BMI, abdominal obesity, and at least one other feature of the metabolic syndrome. Dependency network analysis showed a different pattern of associations between lipidomics, dietary, and clinical variables after the dietary interventions. The most remarkable associations between variables were observed after the diet high in <jats:italic>n<\/jats:italic>\u20103 FA and polyphenols, as the inverse association between gallic acid intake and LDL cholesterol levels, which was indirectly associated with a HDL cluster exclusively comprised lysophospholipids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first human randomized controlled trial showing direct and indirect associations with lipid molecular species and clinical variables of interest in the evaluation of the metabolic syndrome after diets naturally rich in polyphenols.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400155","type":"journal-article","created":{"date-parts":[[2014,6,24]],"date-time":"2014-06-24T21:46:39Z","timestamp":1403646399000},"page":"1873-1882","source":"Crossref","is-referenced-by-count":32,"title":["Isoenergetic diets differing in their <i>n<\/i>\u20103 fatty acid and polyphenol content reflect different plasma and HDL\u2010fraction lipidomic profiles in subjects at high cardiovascular risk"],"prefix":"10.1002","volume":"58","author":[{"given":"Isabel","family":"Bondia\u2010Pons","sequence":"first","affiliation":[{"name":"VTT Technical Research Centre of Finland  Espoo Finland"},{"name":"Department of Food Science and Physiology Research Building, University of Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"P\u00f6h\u00f6","sequence":"additional","affiliation":[{"name":"VTT Technical Research Centre of Finland  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lutgarda","family":"Bozzetto","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Vetrani","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Patti","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna\u2010Marja","family":"Aura","sequence":"additional","affiliation":[{"name":"VTT Technical Research Centre of Finland  Espoo Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Annuzzi","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuulia","family":"Hy\u00f6tyl\u00e4inen","sequence":"additional","affiliation":[{"name":"VTT Technical Research Centre of Finland  Espoo Finland"},{"name":"Steno Diabetes Center  Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Albarosa","family":"Rivellese","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery Federico II University  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Ore\u0161i\u010d","sequence":"additional","affiliation":[{"name":"VTT Technical Research Centre of Finland  Espoo Finland"},{"name":"Steno Diabetes Center  Gentofte Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.149633"},{"key":"e_1_2_7_3_1","first-page":"1137","article-title":"Role of fatty acids and polyphenols in inflammatory gene transcription and their impact on obesity, metabolic syndrome and diabetes","volume":"16","author":"Sears B.","year":"2012","journal-title":"Eur. 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