{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:57:43Z","timestamp":1787590663626,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea","award":["HI13C1527"],"award-info":[{"award-number":["HI13C1527"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Sulforaphane (SFN) is a naturally occurring isothiocynate compound found in cruciferous vegetables. Here, we report the effect of SFN on cardiac hypertrophy and propose an underlying mechanism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>SFN suppresses cardiomyocyte hypertrophy induced by hypertrophic stimuli in vitro and in vivo. SFN suppresses the expression of fetal genes, including atrial natriuretic peptide, brain natriuretic peptide, and beta myosin heavy chain. We used an siRNA technique and atrial natriuretic peptide promoter with mutated GATA binding sites to demonstrate that SFN mediates cardiac hypertrophy by modulating transcription factors GATA4\/6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that SFN has the potential to prevent cardiac hypertrophy by downregulating GATA4\/6 and mitogen\u2010activated protein kinase signaling pathways.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400279","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T10:40:19Z","timestamp":1413888019000},"page":"221-230","source":"Crossref","is-referenced-by-count":14,"title":["Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4\/GATA6 expression and MAPK signaling pathways"],"prefix":"10.1002","volume":"59","author":[{"given":"Hae Jin","family":"Kee","sequence":"first","affiliation":[{"name":"Cardiovascular Convergence Research Center Chonnam National University Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwi Ran","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Convergence Research Center Chonnam National University Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In Kyeom","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Cardiovascular Research Institute Kyungpook National University School of Medicine  Daegu South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Ho","family":"Jeong","sequence":"additional","affiliation":[{"name":"Cardiovascular Convergence Research Center Chonnam National University Hospital  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1983"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.3.865-878.2005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.01.021"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M102174200"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.220764"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/rp.59.1.105"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000072977.86706.23"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2011.02311.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nure.12060"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0755"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2012.07.040"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0641-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.10.007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15117792"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000338570.27156.84"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.03.027"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611198200"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.08.022"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-013-3849-4"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.12659\/AOT.889342"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.11.009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61084"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.8231"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.109.189480"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/128_2012_339"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021110300652"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01123-2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.22.14057"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1158\/1535-7163.1239.3.10","article-title":"The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice","volume":"3","author":"Pham N. 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