{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T11:17:47Z","timestamp":1696418267144},"reference-count":58,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,11,2]],"date-time":"2014-11-02T00:00:00Z","timestamp":1414886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute for Agronomic Research (INRA)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Mild folate deficiency and subsequently elevated plasma level of homocysteine are associated with an increased risk for vascular diseases in adults. Conversely, high intakes of folic acid (FA) may have beneficial effects on vascular function, presumably in part through homocysteine lowering. However, these effects have not yet been translated in terms of prevention or treatment of vascular pathologies. Besides, the complex biologic perturbation induced by variations of the folate supply is still not fully deciphered. We thus carried out a proteomic analysis of the aorta of adult rats after a dietary FA depletion or supplementation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Nine month\u2010old rats were fed a FA\u2010depleted, FA\u2010supplemented or control diet for 8 weeks. Total proteins from adventitia\u2010free aortas were separated by 2DE and differentially expressed proteins were identified by MS. FA depletion or supplementation resulted in significantly changed abundance of 29 spots (<jats:italic>p<\/jats:italic> &lt; 0.05), of which 20 proteins were identified. Bioinformatic analysis revealed that most of these proteins are involved in cytoskeleton\u2010related processes important to cell function\/maintenance, assembly\/organization, and movement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our proteomic study supports that expression of proteins essential to vascular structure and, presumably, function is modulated by high intake as well as deprivation of FA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400317","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T09:35:58Z","timestamp":1412069758000},"page":"2307-2319","source":"Crossref","is-referenced-by-count":2,"title":["Proteomic analysis identifies cytoskeleton\u2010interacting proteins as major downstream targets of altered folate status in the aorta of adult rat"],"prefix":"10.1002","volume":"58","author":[{"given":"Nicolas","family":"G\u00e9rard","sequence":"first","affiliation":[{"name":"Human Nutrition Unit UMR 1019 National Institute for Agronomic Research University of Auvergne  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Chanson\u2010Roll\u00e9","sequence":"additional","affiliation":[{"name":"VAB\u2010nutrition  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond","family":"Rock","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit UMR 1019 National Institute for Agronomic Research University of Auvergne  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Brachet","sequence":"additional","affiliation":[{"name":"Human Nutrition Unit UMR 1019 National Institute for Agronomic Research University of Auvergne  Clermont\u2010Ferrand France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,11,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.04.011"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.5.1563S"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1079\/NRR200478"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.08.008"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.157180"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334586"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-005-1380-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.12.007"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.679084"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2011.10719939"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00809-3"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01075-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.725481"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001177"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016473"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.3.610"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-010-9151-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq0302.105369"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32831cec62"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.3.517"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.187286"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.208"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000182"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.11.2524"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.08.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-007-0651-1"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114500002518"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/clinchem\/45.2.290","article-title":"Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting","volume":"45","author":"Pfeiffer C. 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