{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:08:04Z","timestamp":1790683684778,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T00:00:00Z","timestamp":1411344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Autonomous Community of the Balearic Islands"},{"name":"Fundaci\u00c3\u00b3n Ram\u00c3\u00b3n Areces"},{"name":"Spanish Government","award":["AGL2012-33692"],"award-info":[{"award-number":["AGL2012-33692"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>We studied \u03b2\u2010carotene (BC) absorption and metabolism and compared BC and retinyl palmitate (RE) for their impact on white adipose tissue (WAT) development in suckling rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Rat pups received daily orally from days 1\u201320 of life either the vehicle or vitamin A (approx. \u00d73 that ingested daily from maternal milk) in the form of BC or RE. Intact BC was found in serum and liver of BC\u2010supplemented rats. Both BC and RE supplementation increased retinoic acid mediated transcriptional responses in intestine (on Isx and Bco1) and the liver (on Cyp26a1 and Cpt1a). In contrast, responses in WAT were dependent on the vitamin A source: WAT of BC\u2010supplemented rats, like WAT of control rats, was enriched in larger adipocytes with increased adipogenic markers (peroxisome proliferator\u2010activated receptor \u03b3 and downstream genes) and reduced markers of proliferative status (proliferating cell nuclear antigen) compared to WAT of RE\u2010supplemented rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BC is partly absorbed intact by suckling rats, which resembles the situation in humans and suggests that suckling rats may be an appropriate animal model to study BC uptake, metabolism and biological activity, particularly in infants. Vitamin A supplementation with BC or RE in early life differentially affects WAT and may thus entail different outcomes regarding adiposity programming.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400457","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T19:02:06Z","timestamp":1409166126000},"page":"2157-2165","source":"Crossref","is-referenced-by-count":22,"title":["\u03b2\u2010Carotene during the suckling period is absorbed intact and induces retinoic acid dependent responses similar to preformed vitamin A in intestine and liver, but not adipose tissue of young rats"],"prefix":"10.1002","volume":"58","author":[{"given":"Hana","family":"Mu\u0161inovi\u0107","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology Nutrition and Biotechnology Nutrigenomics\u2010group Universitat de les Illes Balears, and CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn) Palma de Mallorca Spain"},{"name":"Department of Pharmacology School of Medicine Case Western Reserve University Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Luisa","family":"Bonet","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology Nutrition and Biotechnology Nutrigenomics\u2010group Universitat de les Illes Balears, and CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn) Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Granados","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology Nutrition and Biotechnology Nutrigenomics\u2010group Universitat de les Illes Balears, and CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn) Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Amengual","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine Case Western Reserve University Cleveland OH USA"},{"name":"The Leon H. Charney Division of Cardiology New York University School of Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"von Lintig","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Medicine Case Western Reserve University Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Ribot","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology Nutrition and Biotechnology Nutrigenomics\u2010group Universitat de les Illes Balears, and CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn) Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreu","family":"Palou","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology Nutrition and Biotechnology Nutrigenomics\u2010group Universitat de les Illes Balears, and CIBER de Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERobn) Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-2290-x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.06.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-080508-141027"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12263-009-0128-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.12.2271"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20242"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.7"},{"issue":"3","key":"e_1_2_7_9_1","first-page":"S52","article-title":"The possibility of active form of vitamins A and D as suppressors on adipocyte development via ligand\u2010dependent transcriptional regulators","volume":"20","author":"Kawada T.","year":"1996","journal-title":"Int. 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