{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:55:49Z","timestamp":1768748149118,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T00:00:00Z","timestamp":1425340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science, ICT & Future Planning","award":["#2014R1A2A2A01006774"],"award-info":[{"award-number":["#2014R1A2A2A01006774"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Green tea (GT) consumption helps to prevent and control obesity by stimulating hepatic lipid metabolism. However, GT\u2010induced changes in serum and liver metabolomes associated with the anti\u2010obesity effects are not clearly understood. The aim of this study was to identify and validate metabolomic profiles in the livers and sera of GT\u2010fed obese mice to elucidate the relationship between GT consumption and obesity prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Serum and liver metabolites were analyzed in mice fed normal diet, high\u2010fat diet (HFD), HFD with GT, and HFD with crude catechins, using LC\u2010quadrupole TOF MS. The addition of 1% GT to HFD reduced adipose tissue and the levels of blood triglycerides, glucose, insulin, and leptin elevated in HFD\u2010fed mice. We proposed an HFD\u2010induced obesity pathway and validated it by investigating the key regulatory enzymes of mitochondrial \u03b2\u2010oxidation: carnitine palmitoyltransferase\u20101 and \u20102, acyl\u2010coenzyme A dehydrogenase, and acetyl\u2010coenzyme A acyltransferase. The results showed that HFD\u2010induced abnormal mitochondrial \u03b2\u2010oxidation was moderated by the consumption of caffeine\u2010 and theanine\u2010enriched GT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Results of LC\/MS\u2010based metabolomic analysis of obese mice showed changes associated with abnormal lipid and energy metabolism, which were alleviated by GT intake, indicating the mechanism underlying the anti\u2010obesity effects of GT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400470","type":"journal-article","created":{"date-parts":[[2015,1,28]],"date-time":"2015-01-28T13:31:45Z","timestamp":1422451905000},"page":"784-794","source":"Crossref","is-referenced-by-count":60,"title":["Green tea changes serum and liver metabolomic profiles in mice with high\u2010fat diet\u2010induced obesity"],"prefix":"10.1002","volume":"59","author":[{"given":"Lan\u2010Sook","family":"Lee","sequence":"first","affiliation":[{"name":"Korea Food Research Institute Bundang\u2010gu  Seongnam Gyeonggi Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hea","family":"Choi","sequence":"additional","affiliation":[{"name":"Korea Food Research Institute Bundang\u2010gu  Seongnam Gyeonggi Republic of Korea"},{"name":"Department of Food Biotechnology University of Science and Technology  Yuseong\u2010gu Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi Jeong","family":"Sung","sequence":"additional","affiliation":[{"name":"Korea Food Research Institute Bundang\u2010gu  Seongnam Gyeonggi Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Young","family":"Hur","sequence":"additional","affiliation":[{"name":"Korea Food Research Institute Bundang\u2010gu  Seongnam Gyeonggi Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeng 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