{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:32:49Z","timestamp":1780497169716,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T00:00:00Z","timestamp":1430092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Science Centre, Poland","award":["798\/N-COST\/2010\/0"],"award-info":[{"award-number":["798\/N-COST\/2010\/0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Reports on the protective effect of certain foods on brain functions are numerous; however, the permeability of the brain barriers by food components is still hardly recognised. There have been in vitro studies aimed at demonstrating this possibility, but not much is known about this phenomenon in in vivo systems. The objective of the study was to determine the metabolites of dietary quercetin (Q) in urine, blood plasma and cerebrospinal fluid (CSF) after intra\u2010rumen administration of Q rich onion dry skin in an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Eleven sheep had permanently implanted cannulas in the third ventricle of the brain as the means for CSF collection. The animals were administered Q at the dose of 10 mg\/kg bwt. For 12 h the concentration of Q metabolites was measured in urine, blood plasma, and CSF. It was demonstrated that while in blood plasma Q and isorhamnetin mono\u2010glucuronides or mono\u2010sulphates were the main metabolites (80%), in CSF their aglycones were the dominating ones (88%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Q and IR aglycones are the main Q metabolites present in CSF after dietary Q intake. Their passive transport through blood\u2013CSF barrier or a de\u2010conjugating mechanism within that barrier may be involved.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400567","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T10:07:24Z","timestamp":1425031644000},"page":"1088-1094","source":"Crossref","is-referenced-by-count":17,"title":["Quercetin and isorhamnetin aglycones are the main metabolites of dietary quercetin in cerebrospinal fluid"],"prefix":"10.1002","volume":"59","author":[{"given":"Wies\u0142aw","family":"Wiczkowski","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biodynamics of Food Institute of Animal Reproduction and Food Research, Polish Academy of Sciences  Olsztyn Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Skipor","sequence":"additional","affiliation":[{"name":"Department of Local Physiological Regulations Institute of Animal Reproduction and Food Research, Polish Academy of Sciences  Olsztyn Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Misztal","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences  Jablonna Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Szawara\u2010Nowak","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biodynamics of Food Institute of Animal Reproduction and Food Research, Polish Academy of Sciences  Olsztyn Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Topolska","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biodynamics of Food Institute of Animal Reproduction and Food Research, Polish Academy of Sciences  Olsztyn Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz K.","family":"Piskula","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biodynamics of Food Institute of Animal Reproduction and Food Research, Polish Academy of Sciences  Olsztyn Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760600794287"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063535"},{"key":"e_1_2_6_4_1","first-page":"431","article-title":"Transfer of dopamine by counter\u2010current mechanism in the ewe changes with endocrine stage","volume":"16","author":"Skipor J.","year":"2001","journal-title":"Biog. 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