{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:30:29Z","timestamp":1787563829799,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":217,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["35963"],"award-info":[{"award-number":["35963"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Nutr. Food Res."],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1002\/mnfr.201400590","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T02:22:06Z","timestamp":1418091726000},"page":"490-500","source":"Crossref","is-referenced-by-count":16,"title":["Folates from metabolically engineered rice: A long-term study in rats"],"prefix":"10.1002","volume":"59","author":[{"given":"Filip","family":"Kiekens","sequence":"first","affiliation":[{"name":"Laboratory of Toxicology; Ghent University; Ottergemsesteenweg Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Blancquaert","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Plant Biology; Department of Physiology; Ghent University; K.L. Ledeganckstraat Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Devisscher","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology; Ghent University; De Pintelaan Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Van Daele","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology; Ghent University; Ottergemsesteenweg Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique V.","family":"Stove","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology; Microbiology and Immunology; Ghent University; De Pintelaan Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris R.","family":"Delanghe","sequence":"additional","affiliation":[{"name":"Department of Clinical Biology; Microbiology and Immunology; Ghent University; De Pintelaan Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Van Der Straeten","sequence":"additional","affiliation":[{"name":"Laboratory of Functional Plant Biology; Department of Physiology; Ghent University; K.L. Ledeganckstraat Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy E.","family":"Lambert","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology; Ghent University; Ottergemsesteenweg Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe P.","family":"Stove","sequence":"additional","affiliation":[{"name":"Laboratory of Toxicology; Ghent University; Ottergemsesteenweg Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"10.1002\/mnfr.201400590-BIB0001|mnfr2312-cit-0001","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/nbt1351","article-title":"Folate fortification of rice by metabolic engineering","volume":"25","author":"Storozhenko","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1002\/mnfr.201400590-BIB0002|mnfr2312-cit-0002","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.nbt.2011.11.012","article-title":"Potential impact and cost-effectiveness of multi-biofortified rice in China","volume":"29","author":"Steur","year":"2012","journal-title":"New. Biotechnol."},{"key":"10.1002\/mnfr.201400590-BIB0003|mnfr2312-cit-0003","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nbt0610-554","article-title":"Health impact in China of folate-biofortified rice","volume":"28","author":"Steur","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1002\/mnfr.201400590-BIB0004|mnfr2312-cit-0004","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1073\/pnas.0712330105","article-title":"Biofortified and bioavailable: the gold standard for plant-based diets","volume":"105","author":"Jeong","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1002\/mnfr.201400590-BIB0005|mnfr2312-cit-0005","doi-asserted-by":"crossref","first-page":"506S","DOI":"10.1093\/jn\/132.3.506S","article-title":"Golden Rice: introducing the beta-carotene biosynthesis pathway into rice endosperm by genetic engineering to defeat vitamin A deficiency","volume":"132","author":"Beyer","year":"2002","journal-title":"J. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0006|mnfr2312-cit-0006","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.3945\/ajcn.2008.27119","article-title":"Golden Rice is an effective source of vitamin A","volume":"89","author":"Tang","year":"2009","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0007|mnfr2312-cit-0007","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1093\/jn\/135.12.2823","article-title":"Iron-Biofortified Rice Improves the Iron Stores of Nonanemic Filipino Women","volume":"135","author":"Haas","year":"2005","journal-title":"J. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0008|mnfr2312-cit-0008","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1073\/pnas.0709005105","article-title":"Nutritional impact of elevated calcium transport activity in carrots","volume":"105","author":"Morris","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/mnfr.201400590-BIB0009|mnfr2312-cit-0009","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11130-013-0402-9","article-title":"Natural folates from biofortified tomato and synthetic 5-methyl-tetrahydrofolate display equivalent bioavailability in a murine model","volume":"69","author":"Castorena-Torres","year":"2014","journal-title":"Plant. Food. Hum. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0010|mnfr2312-cit-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1201\/9781420071252-c1","volume-title":"Folate in Health and Disease","author":"Shane","year":"2009"},{"key":"10.1002\/mnfr.201400590-BIB0011|mnfr2312-cit-0011","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev-physiol-020911-153251","article-title":"The intestinal absorption of folates","volume":"76","author":"Visentin","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"10.1002\/mnfr.201400590-BIB0012|mnfr2312-cit-0012","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0305-0491(93)90121-K","article-title":"Antioxidant systems and erythrocyte life-span in mammals","volume":"106","author":"Kurata","year":"1993","journal-title":"Comp. Biochem. Phys. B"},{"key":"10.1002\/mnfr.201400590-BIB0013|mnfr2312-cit-0013","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.blre.2014.01.002","article-title":"Abnormal erythropoiesis and the pathophysiology of chronic anemia","volume":"28","author":"Koury","year":"2014","journal-title":"Blood Rev."},{"key":"10.1002\/mnfr.201400590-BIB0014|mnfr2312-cit-0014","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/qjmed\/90.8.519","article-title":"Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid","volume":"90","author":"Ward","year":"1997","journal-title":"QJM"},{"key":"10.1002\/mnfr.201400590-BIB0015|mnfr2312-cit-0015","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/mnfr.201200636","article-title":"Methyl nutrients, DNA methylation and cardiovascular disease","volume":"58","author":"Glier","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1002\/mnfr.201400590-BIB0016|mnfr2312-cit-0016","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/jn\/129.4.779","article-title":"Folate metabolism and requirements","volume":"129","author":"Bailey","year":"1999","journal-title":"J. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0017|mnfr2312-cit-0017","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1021\/jf0341621","article-title":"Plasma homocysteine and glycine are sensitive indices of folate status in a rodent model of folate depletion and repletion","volume":"51","author":"House","year":"2003","journal-title":"J. Agric. Food. Chem."},{"key":"10.1002\/mnfr.201400590-BIB0018|mnfr2312-cit-0018","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1093\/jn\/119.12.1956","article-title":"Repletion of folate-depleted rats with an amino acid-based diet supplemented with folic acid","volume":"119","author":"Clifford","year":"1989","journal-title":"J. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0019|mnfr2312-cit-0019","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jfoodeng.2011.07.032","article-title":"Folic acid fortification of parboiled rice: Multifactorial analysis and kinetic investigation","volume":"108","author":"Kam","year":"2012","journal-title":"J. Food Eng."},{"key":"10.1002\/mnfr.201400590-BIB0020|mnfr2312-cit-0020","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1021\/ac303014b","article-title":"Prediction of the hematocrit of dried blood spots via potassium measurement on a routine clinical chemistry analyzer","volume":"85","author":"Capiau","year":"2013","journal-title":"Anal. Chem."},{"key":"10.1002\/mnfr.201400590-BIB0021|mnfr2312-cit-0021","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jchromb.2009.12.032","article-title":"Ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS\/MS) for the sensitive determination of folates in rice","volume":"878","author":"Brouwer","year":"2010","journal-title":"J. Chromatogr. B"},{"key":"10.1002\/mnfr.201400590-BIB0022|mnfr2312-cit-0022","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1021\/jf960633q","article-title":"Determination of folate in cereal-grain food products using trienzyme extraction and combined affinity and reversed-phase liquid chromatography","volume":"45","author":"Pfeiffer","year":"1997","journal-title":"J. Agric. Food Chem."},{"key":"10.1002\/mnfr.201400590-BIB0023|mnfr2312-cit-0023","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.cccn.2004.11.028","article-title":"Evaluation of an enzymatic homocysteine assay for the Hitachi series chemistry analyzer","volume":"354","author":"Kellog","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"10.1002\/mnfr.201400590-BIB0024|mnfr2312-cit-0024","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1093\/clinchem\/46.8.1277","article-title":"Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate","volume":"46","author":"Klee","year":"2000","journal-title":"Clin. Chem."},{"key":"10.1002\/mnfr.201400590-BIB0025|mnfr2312-cit-0025","unstructured":"Harlan Laboratories [Internet] Indianapolis (IN): Harlan Laboratories; c2008. HsdHanWIST_datasheet_(03-11).pdf; 2011 Mar 21 [cited 2014 Aug 12] [2 p.]. Available from: http:\/\/www.harlan.com\/download.axd\/3848f9a445614166814c4b26a31c81e2.pdf?d=HsdHanWIST%20datasheet%20(03--2011)"},{"key":"10.1002\/mnfr.201400590-BIB0026|mnfr2312-cit-0026","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1172\/JCI109467","article-title":"Kinetics of the normal folate enterohepatic cycle","volume":"64","author":"Steinberg","year":"1979","journal-title":"J. Clin. Invest"},{"key":"10.1002\/mnfr.201400590-BIB0027|mnfr2312-cit-0027","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/jn\/115.6.814","article-title":"Comparison of folate conjugase activities in human, pig, rat and monkey intestine","volume":"115","author":"Wang","year":"1985","journal-title":"J. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0028|mnfr2312-cit-0028","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/ajcn\/84.1.167","article-title":"The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation","volume":"84","author":"McKillop","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0029|mnfr2312-cit-0029","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jcs.2008.12.001","article-title":"Bioavailability of ferulic acid is determined by its bioaccessibility","volume":"49","author":"Anson","year":"2009","journal-title":"J. Cereal Sci."},{"key":"10.1002\/mnfr.201400590-BIB0030|mnfr2312-cit-0030","doi-asserted-by":"crossref","first-page":"1376S","DOI":"10.1093\/jn\/131.4.1376S","article-title":"Case study: folate bioavailability","volume":"131","author":"Gregory","year":"2001","journal-title":"J. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0031|mnfr2312-cit-0031","first-page":"1991","article-title":"Rate of starch hydrolysis in vitro as a predictor of metabolic responses to complex carbohydrate in vivo","volume":"34","author":"O'Dea","year":"1981","journal-title":"AJCN"},{"key":"10.1002\/mnfr.201400590-BIB0032|mnfr2312-cit-0032","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0020-711X(74)90056-1","article-title":"Trypanosoma lewisi: body weight gains and food consumption of folate-deficient rats","volume":"5","author":"Aboko-Cole","year":"1974","journal-title":"Int. J. Biochem."},{"key":"10.1002\/mnfr.201400590-BIB0033|mnfr2312-cit-0033","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/ajcn.70.2.198","article-title":"Estimated folate intakes: data updated to reflect food fortification, increased bioavailability, and dietary supplement use","volume":"70","author":"Lewis","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0034|mnfr2312-cit-0034","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/jn\/135.3.619","article-title":"Differential kinetic behavior and distribution for pteroylglutamic acid and reduced folates: a revised hypothesis of the primary site of PteGlu metabolism in humans","volume":"135","author":"Wright","year":"2005","journal-title":"J. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0035|mnfr2312-cit-0035","doi-asserted-by":"crossref","first-page":"1455S","DOI":"10.3945\/ajcn.2010.28674E","article-title":"Folate bioavailability: implications for establishing dietary recommendations and optimizing status","volume":"91","author":"Caudill","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0036|mnfr2312-cit-0036","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1093\/ajcn\/65.6.1790","article-title":"Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements","volume":"65","author":"Kelly","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0037|mnfr2312-cit-0037","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1182\/blood.V79.9.2273.2273","article-title":"Dessypris E., Ineffective hematopoiesis in folate-deficient mice","volume":"79","author":"Bills","year":"1992","journal-title":"Blood"},{"key":"10.1002\/mnfr.201400590-BIB0038|mnfr2312-cit-0038","first-page":"409","volume-title":"Folates in Health and Disease","author":"Stabler","year":"2010"},{"key":"10.1002\/mnfr.201400590-BIB0039|mnfr2312-cit-0039","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/ajcn\/85.2.465","article-title":"Bioavailability of food folates is 80% of that of folic acid","volume":"85","author":"Winkels","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1002\/mnfr.201400590-BIB0040|mnfr2312-cit-0040","unstructured":"WHO Serum and Red Blood Cell Folate Concentrations for Assessing Folate Status in Populations World Health Organisation 2012 1 5"},{"key":"10.1002\/mnfr.201400590-BIB0041|mnfr2312-cit-0041","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/mnfr.201200125","article-title":"The relationship between intracellular and plasma levels of folate and metabolites in the methionine cycle: a model","volume":"57","author":"Duncan","year":"2013","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1002\/mnfr.201400590-BIB0042|mnfr2312-cit-0042","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1042\/bj2980415","article-title":"Folate-deficiency- induced homocysteinaemia in rats: disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism","volume":"298","author":"Miller","year":"1994","journal-title":"Biochem. J."},{"key":"10.1002\/mnfr.201400590-BIB0043|mnfr2312-cit-0043","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1182\/blood.V89.12.4617","article-title":"Apoptosis of Late-Stage Erythroblasts in Megaloblastic Anemia: Association With DNA Damage and Macrocyte Production","volume":"89","author":"Koury","year":"1997","journal-title":"Blood"},{"key":"10.1002\/mnfr.201400590-BIB0044|mnfr2312-cit-0044","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/jn\/132.6.1361","article-title":"Severe Folate Deficiency Impairs Natural Killer Cell-Mediated Cytotoxicity in Rats","volume":"132","author":"Kim","year":"2002","journal-title":"J. Nutr."}],"container-title":["Molecular Nutrition & Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201400590","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/mnfr.201400590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T11:43:14Z","timestamp":1625312594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201400590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,27]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"URL":"https:\/\/doi.org\/10.1002\/mnfr.201400590","relation":{},"ISSN":["1613-4125"],"issn-type":[{"value":"1613-4125","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,27]]}}}