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LPS\u2010induced AKI is associated with an abnormal inflammatory response, including renal endothelial dysfunction and renal inflammation. Resveratrol, a natural phytoalexin with low toxicity and anti\u2010inflammatory properties, is known to protect endothelial cells and modulate the immune response in sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>This study investigates the potential protective effects of resveratrol on AKI induced by LPS exposure of mice. Resveratrol was administered as a pre\u2010 and posttreatment, or as a posttreatment alone following LPS injection and compared to control groups. Resveratrol significantly improved kidney function and lowered serum and kidney tissue inflammatory cytokine levels. Consistently, resveratrol prevented endotoxin\u2010induced disruption of endothelial cell permeability and inhibited inflammation of kidney tissue. Resveratrol treatment attenuated the effects of LPS on macrophages, with significant inhibition of activation, cytokine release, and Toll\u2010like receptor 4 activation. Resveratrol treatment also resulted in decreased expression of iNOS, Bcl\u20102, and Bcl\u2010xL in macrophages, which was linked with induction of apoptosis in macrophages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our studies suggest that resveratrol might represent a novel therapeutic agent to prevent and treat sepsis\u2010induced AKI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201400819","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T11:37:00Z","timestamp":1422358620000},"page":"853-864","source":"Crossref","is-referenced-by-count":99,"title":["Resveratrol attenuates lipopolysaccharide\u2010induced acute kidney injury by suppressing inflammation driven by macrophages"],"prefix":"10.1002","volume":"59","author":[{"given":"Liang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology Renmin Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Zumbrun","sequence":"additional","affiliation":[{"name":"Department of Pathology Microbiology and Immunology University of South Carolina School of Medicine  Columbia SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pathology Microbiology and Immunology University of South Carolina School of Medicine  Columbia SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash S.","family":"Nagarkatti","sequence":"additional","affiliation":[{"name":"Department of Pathology Microbiology and Immunology University of South Carolina School of Medicine  Columbia SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitzi","family":"Nagarkatti","sequence":"additional","affiliation":[{"name":"Department of Pathology Microbiology and Immunology University of South Carolina School of Medicine  Columbia SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01326"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010050484"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e3282f4db7a"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.5.1579"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000440"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318168ccd5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.33549\/physiolres.931936","article-title":"New developments in septic acute kidney injury","volume":"59","author":"Chvojka J.","year":"2010","journal-title":"Physiol. 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