{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:07:25Z","timestamp":1790521645734,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Nutr. Food Res."],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1002\/mnfr.201500304","type":"journal-article","created":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T06:55:13Z","timestamp":1442559313000},"page":"2537-2546","source":"Crossref","is-referenced-by-count":69,"title":["Preventive effects of dietary hydroxytyrosol acetate, an extra virgin olive oil polyphenol in murine collagen-induced arthritis"],"prefix":"10.1002","volume":"59","author":[{"given":"Mar\u00eda Angeles","family":"Rosillo","sequence":"first","affiliation":[{"name":"Department of Pharmacology; Faculty of Pharmacy; University of Seville; Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"S\u00e1nchez-Hidalgo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; Faculty of Pharmacy; University of Seville; Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gonz\u00e1lez-Benjumea","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry; Faculty of Chemistry; University of Seville; Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 G.","family":"Fern\u00e1ndez-Bola\u00f1os","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry; Faculty of Chemistry; University of Seville; Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Lubberts","sequence":"additional","affiliation":[{"name":"Department of Rheumatology; Erasmus MC; University Medical Center; Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Alarc\u00f3n-de-la-Lastra","sequence":"additional","affiliation":[{"name":"Department of Pharmacology; Faculty of Pharmacy; University of Seville; Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,12]]},"reference":[{"key":"10.1002\/mnfr.201500304-BIB0001|mnfr2496-cit-0001","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1002\/mnfr.201500304-BIB0002|mnfr2496-cit-0002","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/BOR.0000000000000174","article-title":"New pathogenic insights into rheumatoid arthritis","volume":"27","author":"Jutley","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1002\/mnfr.201500304-BIB0003|mnfr2496-cit-0003","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/1871530315666150316121808","article-title":"TNF as a target of inflammation in rheumatoid arthritis","volume":"15","author":"Yamanaka","year":"2015","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1002\/mnfr.201500304-BIB0004|mnfr2496-cit-0004","doi-asserted-by":"crossref","DOI":"10.1007\/s00394-015-0850-0","article-title":"Dietary extra-virgin olive oil prevents inflammatory response and cartilage matrix degradation in murine collagen-induced arthritis","author":"Rosillo","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"10.1002\/mnfr.201500304-BIB0005|mnfr2496-cit-0005","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.trsl.2012.06.001","article-title":"Inhibitory effect of the antimalarial agent artesunate on collagen-induced arthritis in rats through nuclear factor kappa B and mitogen-activated protein kinase signaling pathway","volume":"161","author":"Li","year":"2013","journal-title":"Transl. Res."},{"key":"10.1002\/mnfr.201500304-BIB0006|mnfr2496-cit-0006","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/art.38327","article-title":"Alternative p38 MAPKs are essential for collagen-induced arthritis","volume":"66","author":"Criado","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1002\/mnfr.201500304-BIB0007|mnfr2496-cit-0007","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1172\/JCI0215528","article-title":"The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis","volume":"110","author":"McCoy","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1002\/mnfr.201500304-BIB0008|mnfr2496-cit-0008","article-title":"IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis","author":"Anderson","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1002\/mnfr.201500304-BIB0009|mnfr2496-cit-0009","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1073\/pnas.161272598","article-title":"Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia","volume":"98","author":"Minamino","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1002\/mnfr.201500304-BIB0010|mnfr2496-cit-0010","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.jnutbio.2014.07.006","article-title":"Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis","volume":"25","author":"Rosillo","year":"2014","journal-title":"J. Nutr. Biochem."},{"key":"10.1002\/mnfr.201500304-BIB0011|mnfr2496-cit-0011","doi-asserted-by":"crossref","first-page":"10960","DOI":"10.1021\/jf8020267","article-title":"New lipophilic tyrosyl esters. Comparative antioxidant evaluation with hydroxytyrosyl esters","volume":"56","author":"Mateos","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1002\/mnfr.201500304-BIB0012|mnfr2496-cit-0012","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bioorg.2006.09.003","article-title":"Hydroxytyrosol lipophilic analogues: enzymatic synthesis, radical scavenging activity and DNA oxidative damage protection","volume":"35","author":"Grasso","year":"2007","journal-title":"Bioorg. Chem."},{"key":"10.1002\/mnfr.201500304-BIB0013|mnfr2496-cit-0013","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s12010-010-9065-2","article-title":"Hydroxytyrosol acyl esters: biosynthesis and activities","volume":"163","author":"Bouallagui","year":"2011","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1002\/mnfr.201500304-BIB0014|mnfr2496-cit-0014","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neulet.2008.09.022","article-title":"Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia-reoxygenation","volume":"446","author":"Gonzalez-Correa","year":"2008","journal-title":"Neurosci. Lett."},{"key":"10.1002\/mnfr.201500304-BIB0015|mnfr2496-cit-0015","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1017\/S0007114508061539","article-title":"Virgin olive oil polyphenol hydroxytyrosol acetate inhibits in vitro platelet aggregation in human whole blood: comparison with hydroxytyrosol and acetylsalicylic acid","volume":"101","author":"Correa","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1002\/mnfr.201500304-BIB0016|mnfr2496-cit-0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2014.12.001","article-title":"Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice","author":"Sanchez-Fidalgo","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"10.1002\/mnfr.201500304-BIB0017|mnfr2496-cit-0017","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1021\/jf503357s","article-title":"Naturally occurring hydroxytyrosol derivatives: hydroxytyrosyl acetate and 3,4-dihydroxyphenylglycol modulate inflammatory response in murine peritoneal macrophages. Potential utility as new dietary supplements","volume":"63","author":"Aparicio-Soto","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1002\/mnfr.201500304-BIB0018|mnfr2496-cit-0018","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.2741\/4054","article-title":"IL-6, IL-17 and STAT3: a holy trinity in auto-immunity?","volume":"17","author":"Camporeale","year":"2012","journal-title":"Front. Biosci."},{"key":"10.1002\/mnfr.201500304-BIB0019|mnfr2496-cit-0019","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1136\/ard.2007.082412","article-title":"Treatment with a CO-releasing molecule (CORM-3) reduces joint inflammation and erosion in murine collagen-induced arthritis","volume":"67","author":"Ferrandiz","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1002\/mnfr.201500304-BIB0020|mnfr2496-cit-0020","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1021\/jf990009o","article-title":"Phenolic compounds in Spanish olive oils","volume":"47","author":"Brenes","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"10.1002\/mnfr.201500304-BIB0021|mnfr2496-cit-0021","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.foodchem.2010.09.054","article-title":"Acetylation of hydroxytyrosol enhances its transport across differentiated Caco-2 cell monolayers","volume":"125","author":"Mateos","year":"2011","journal-title":"Food Chem."},{"key":"10.1002\/mnfr.201500304-BIB0022|mnfr2496-cit-0022","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.foodchem.2012.02.192","article-title":"A new hydroxytyrosol metabolite identified in human plasma: hydroxytyrosol acetate sulphate","volume":"134","author":"Rubio","year":"2012","journal-title":"Food Chem."},{"key":"10.1002\/mnfr.201500304-BIB0023|mnfr2496-cit-0023","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1089\/jir.2011.0056","article-title":"Collagen-induced arthritis as an animal model for rheumatoid arthritis: focus on interferon-gamma","volume":"31","author":"Schurgers","year":"2011","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1002\/mnfr.201500304-BIB0024|mnfr2496-cit-0024","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/ard.2006.064782","article-title":"High anti-collagen type-II antibody levels and induction of proinflammatory cytokines by anti-collagen antibody-containing immune complexes in vitro characterise a distinct rheumatoid arthritis phenotype associated with acute inflammation at the time of disease onset","volume":"66","author":"Mullazehi","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1002\/mnfr.201500304-BIB0025|mnfr2496-cit-0025","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1002\/eji.200323810","article-title":"Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB","volume":"33","author":"Nandakumar","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1002\/mnfr.201500304-BIB0026|mnfr2496-cit-0026","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/B978-0-12-394299-9.00002-3","article-title":"Autoimmune arthritis: the interface between the immune system and joints","volume":"115","author":"Komatsu","year":"2012","journal-title":"Adv. Immunol."},{"key":"10.1002\/mnfr.201500304-BIB0027|mnfr2496-cit-0027","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.autrev.2013.12.004","article-title":"Th17 and regulatory T cell balance in autoimmune and inflammatory diseases","volume":"13","author":"Noack","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1002\/mnfr.201500304-BIB0028|mnfr2496-cit-0028","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/1756-185X.12132","article-title":"Th17 Cells in Immunopathogenesis and treatment of rheumatoid arthritis","volume":"16","author":"Azizi","year":"2013","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1002\/mnfr.201500304-BIB0029|mnfr2496-cit-0029","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1172\/JCI11066","article-title":"Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha","volume":"106","author":"Cenci","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1002\/mnfr.201500304-BIB0030|mnfr2496-cit-0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1119(03)00841-2","article-title":"Tumor necrosis factor-alpha: molecular and cellular mechanisms in skeletal pathology","volume":"321","author":"Nanes","year":"2003","journal-title":"Gene"},{"key":"10.1002\/mnfr.201500304-BIB0031|mnfr2496-cit-0031","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1621100","article-title":"Increased osteoclast development after estrogen loss: mediation by interleukin-6","volume":"257","author":"Jilka","year":"1992","journal-title":"Science"},{"key":"10.1002\/mnfr.201500304-BIB0032|mnfr2496-cit-0032","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbrc.2004.09.011","article-title":"Effects of IL-1beta on gene expression in human rheumatoid synovial fibroblasts","volume":"324","author":"Jeong","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1002\/mnfr.201500304-BIB0033|mnfr2496-cit-0033","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/rheumatology\/31.9.583","article-title":"Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood","volume":"31","author":"Saxne","year":"1992","journal-title":"Br. J. Rheumatol."},{"key":"10.1002\/mnfr.201500304-BIB0034|mnfr2496-cit-0034","doi-asserted-by":"crossref","first-page":"183653","DOI":"10.1155\/2013\/183653","article-title":"Serum matrix metalloproteinase-3 in comparison with acute phase proteins as a marker of disease activity and radiographic damage in early rheumatoid arthritis","volume":"2013","author":"Ally","year":"2013","journal-title":"Mediators Inflamm."},{"key":"10.1002\/mnfr.201500304-BIB0035|mnfr2496-cit-0035","doi-asserted-by":"crossref","first-page":"537324","DOI":"10.1155\/2014\/537324","article-title":"Could biomarkers of bone, cartilage or synovium turnover be used for relapse prediction in rheumatoid arthritis patients?","volume":"2014","author":"Denarie","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1002\/mnfr.201500304-BIB0036|mnfr2496-cit-0036","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/abbi.2001.2614","article-title":"Biochemical characterization of mouse microsomal prostaglandin E synthase-1 and its colocalization with cyclooxygenase-2 in peritoneal macrophages","volume":"397","author":"Lazarus","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1002\/mnfr.201500304-BIB0037|mnfr2496-cit-0037","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.jbspin.2004.03.004","article-title":"Signal transduction pathways: new targets for treating rheumatoid arthritis","volume":"71","author":"Morel","year":"2004","journal-title":"Joint Bone Spine"},{"key":"10.1002\/mnfr.201500304-BIB0038|mnfr2496-cit-0038","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-065X.2008.00626.x","article-title":"Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics","volume":"223","author":"Feldmann","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1002\/mnfr.201500304-BIB0039|mnfr2496-cit-0039","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/ar300","article-title":"NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction","volume":"3","author":"Makarov","year":"2001","journal-title":"Arthritis Res."},{"key":"10.1002\/mnfr.201500304-BIB0040|mnfr2496-cit-0040","doi-asserted-by":"crossref","first-page":"e56349","DOI":"10.1371\/journal.pone.0056349","article-title":"SKLB023 blocks joint inflammation and cartilage destruction in arthritis models via suppression of nuclear factor-kappa B activation in macrophage","volume":"8","author":"Xie","year":"2013","journal-title":"PloS One"},{"key":"10.1002\/mnfr.201500304-BIB0041|mnfr2496-cit-0041","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","article-title":"Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis","volume":"76","author":"Li","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1002\/mnfr.201500304-BIB0042|mnfr2496-cit-0042","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1172\/JCI12466","article-title":"c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis","volume":"108","author":"Han","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1002\/mnfr.201500304-BIB0043|mnfr2496-cit-0043","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-5793(99)01717-2","article-title":"The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts","volume":"465","author":"Suzuki","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1002\/mnfr.201500304-BIB0044|mnfr2496-cit-0044","doi-asserted-by":"crossref","first-page":"31155","DOI":"10.1074\/jbc.M001229200","article-title":"Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)","volume":"275","author":"Matsumoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1002\/mnfr.201500304-BIB0045|mnfr2496-cit-0045","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1071545","article-title":"A road map for those who don't know JAK-STAT","volume":"296","author":"Aaronson","year":"2002","journal-title":"Science"},{"key":"10.1002\/mnfr.201500304-BIB0046|mnfr2496-cit-0046","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1002\/art.20302","article-title":"Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice","volume":"50","author":"Hooge","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1002\/mnfr.201500304-BIB0047|mnfr2496-cit-0047","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jep.2012.08.037","article-title":"Achyranthes japonica exhibits anti-inflammatory effect via NF-kappaB suppression and HO-1 induction in macrophages","volume":"144","author":"Bang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1002\/mnfr.201500304-BIB0048|mnfr2496-cit-0048","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","article-title":"The Nrf2 regulatory network provides an interface between redox and intermediary metabolism","volume":"39","author":"Hayes","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1002\/mnfr.201500304-BIB0049|mnfr2496-cit-0049","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1089\/ars.2010.3835","article-title":"Deficiency of Nrf2 accelerates the effector phase of arthritis and aggravates joint disease","volume":"15","author":"Maicas","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1002\/mnfr.201500304-BIB0050|mnfr2496-cit-0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s10753-014-0002-3","article-title":"Pemetrexed ameliorates experimental arthritis in rats","volume":"38","author":"Karatas","year":"2015","journal-title":"Inflammation"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201500304","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/mnfr.201500304","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T12:21:47Z","timestamp":1625314907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201500304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,12]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12]]}},"URL":"https:\/\/doi.org\/10.1002\/mnfr.201500304","archive":["Portico"],"relation":{},"ISSN":["1613-4125"],"issn-type":[{"value":"1613-4125","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10,12]]}}}