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However, the underlying mechanisms are still unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      A cross\u2010sectional survey, animal study, and in vitro experiments were conducted to investigate the effect and mechanisms of vitamin D deficiency on endogenous cholesterol metabolism. We demonstrated that vitamin D deficiency was positively associated with an increase of total serum cholesterol and low\u2010density lipoprotein cholesterol levels in northern Chinese individuals. The vitamin D deficiency\u2010induced increase of cholesterol concentration was mainly due to enhanced cholesterol biosynthesis rather than reduced catabolism. Under vitamin D deficiency, the transcriptional activity of vitamin D receptor (VDR) was decreased, leading to the downregulation of insulin\u2010induced gene\u20102 (Insig\u20102) expression and thus its inhibitory role on sterol regulatory element\u2010binding protein 2 activation; 3\u2010hydroxy\u20103\u2010methylglutaryl\u2010coenzyme A reductase expression was accordingly increased. Vitamin D\n                      <jats:sub>3<\/jats:sub>\n                      was protective against vitamin D deficiency\u2010induced cholesterol increase by maintaining the transcriptional activity of VDR and Insig\u20102 expression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D deficiency is associated with the increase of circulating cholesterol in the people of northern China by enhancing hepatic cholesterol biosynthesis, which was linked to the reduction of transcriptional activity of VDR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201500425","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T04:55:05Z","timestamp":1450846505000},"page":"798-809","source":"Crossref","is-referenced-by-count":59,"title":["Increase of circulating cholesterol in vitamin D deficiency is linked to reduced vitamin D receptor activity via the Insig\u20102\/SREBP\u20102 pathway"],"prefix":"10.1002","volume":"60","author":[{"given":"Songtao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Public Health College Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Public Health College Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Public Health College Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyi","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Food Hygiene, Public Health College Harbin Medical 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