{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:03Z","timestamp":1786978383541,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81222052, 81421005"],"award-info":[{"award-number":["81222052, 81421005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangsu Province Science Fund for Distinguished Young Scholars","award":["BK20130025"],"award-info":[{"award-number":["BK20130025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Quercetin is a dietary flavonoid whose role in the regulation of the activity of insulin remains controversial. Our study aimed to investigate how quercetin and its major metabolite quercetin\u20103\u2010glucuronide (Q\u20103\u2010G) regulate insulin\u2010mediated glucose disposal in skeletal muscle under normal and inflammatory conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Under normal conditions, quercetin impaired glucose and insulin tolerance and attenuated insulin\u2010mediated phosphorylation of Akt substrate of 160\u00a0kDa (AS160) and TBC1D1 without affecting Akt activity in male Institute of Cancer Research (ICR) mice. However, under inflammatory conditions, quercetin exhibited an opposite effect in these animals. In C2C12 cells, quercetin also decreased insulin\u2010stimulated AS160 and TBC1D1 phosphorylation and glucose uptake in the absence of an inflammatory insult, whereas it improved the action of insulin under inflammatory conditions. Knockdown of adenosine 5\u2032\u2010monophosphate\u2010activated protein kinase \u03b1 (AMPK\u03b1) blocked the differential effects of quercetin under both conditions. Unlike quercetin, Q\u20103\u2010G had no influence on insulin\u2010induced phosphorylation of AS160 and TBC1D1 and glucose uptake in C2C12 myotubes under normal conditions. Q\u20103\u2010G displayed a similar regulation with quercetin in glucose disposal under inflammatory conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quercetin suppressed insulin\u2010mediated glucose disposal in skeletal muscle tissue\/cells under normal conditions while it ameliorated impaired glucose uptake under inflammatory conditions with activation of AMPK. In contrast, Q\u20103\u2010G ameliorated insulin resistance in skeletal cells under inflammatory conditions without affecting glucose disposal under normal conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201500509","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T04:18:59Z","timestamp":1449029939000},"page":"551-565","source":"Crossref","is-referenced-by-count":28,"title":["Quercetin oppositely regulates insulin\u2010mediated glucose disposal in skeletal muscle under normal and inflammatory conditions: The dual roles of AMPK activation"],"prefix":"10.1002","volume":"60","author":[{"given":"Kang","family":"Liu","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Department of Pharmacology of Chinese Materia Medica China Pharmaceutical University  Nanjing 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