{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:28:34Z","timestamp":1790731714918,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,29]],"date-time":"2015-12-29T00:00:00Z","timestamp":1451347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p><jats:bold>Scope<\/jats:bold>: Inflammatory bowel disease (IBD) constitutes a growing public health concern in western countries. Bacteria with anti\u2010inflammatory properties are lacking in the dysbiosis accompanying IBD. Selected strains of probiotic bacteria with anti\u2010inflammatory properties accordingly alleviate symptoms and enhance treatment of ulcerative colitis in clinical trials. Such properties are also found in selected strains of dairy starters such as <jats:italic>Propionibacterium freudenreichii<\/jats:italic> and <jats:italic>Lactobacillus delbrueckii<\/jats:italic> (Ld). We thus investigated the possibility to develop a fermented dairy product, combining both starter and probiotic abilities of both lactic acid and propionic acid bacteria, designed to extend remissions in IBD patients.<\/jats:p><jats:p><jats:bold>Methods and results<\/jats:bold>: We developed a single\u2010strain Ld\u2010fermented milk and a two\u2010strain <jats:italic>P. freudenreichii<\/jats:italic> and Ld\u2010fermented experimental pressed cheese using strains previously selected for their anti\u2010inflammatory properties. Consumption of these experimental fermented dairy products protected mice against trinitrobenzenesulfonic acid induced colitis, alleviating severity of symptoms, modulating local and systemic inflammation, as well as colonic oxidative stress and epithelial cell damages. As a control, the corresponding sterile dairy matrix failed to afford such protection.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold>: This work reveals the probiotic potential of this bacterial mixture, in the context of fermented dairy products. It opens new perspectives for the reverse engineering development of anti\u2010inflammatory fermented foods designed for target populations with IBD, and has provided evidences leading to an ongoing pilot clinical study in ulcerative colitis patients.<\/jats:p>","DOI":"10.1002\/mnfr.201500580","type":"journal-article","created":{"date-parts":[[2015,12,8]],"date-time":"2015-12-08T16:57:18Z","timestamp":1449593838000},"page":"935-948","source":"Crossref","is-referenced-by-count":65,"title":["Combining selected immunomodulatory <i>Propionibacterium freudenreichii<\/i> and <i>Lactobacillus delbrueckii<\/i> strains: Reverse engineering development of an anti\u2010inflammatory cheese"],"prefix":"10.1002","volume":"60","author":[{"given":"Coline","family":"Pl\u00e9","sequence":"first","affiliation":[{"name":"Institut Pasteur de Lille, Lactic Acid Bacteria &amp; Mucosal Immunity Center for Infection and Immunity of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Breton","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Lille, Lactic Acid Bacteria &amp; Mucosal Immunity Center for Infection and Immunity of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Richoux","sequence":"additional","affiliation":[{"name":"Actalia Produits Laitiers Agrocampus Ouest  Rennes cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Nurdin","sequence":"additional","affiliation":[{"name":"Actalia Produits Laitiers Agrocampus Ouest  Rennes cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie\u2010Marie","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Science et Technologie du Lait et de l\u2019\u0152uf INRA  Rennes France"},{"name":"Agrocampus Ouest  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Falentin","sequence":"additional","affiliation":[{"name":"Science et Technologie du Lait et de l\u2019\u0152uf INRA  Rennes France"},{"name":"Agrocampus Ouest  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Herv\u00e9","sequence":"additional","affiliation":[{"name":"Laboratoires Standa  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Chuat","sequence":"additional","affiliation":[{"name":"Science et Technologie du Lait et de l\u2019\u0152uf INRA  Rennes France"},{"name":"Agrocampus Ouest  Rennes France"},{"name":"CIRM\u2010BIA Centre Internationale de Ressources Microbiennes\u2013Bact\u00e9ries d'Int\u00e9r\u00eat Alimentaire  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riwanon","family":"Lem\u00e9e","sequence":"additional","affiliation":[{"name":"Laboratoires Standa  Caen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Maguin","sequence":"additional","affiliation":[{"name":"INRA  Jouy\u2010en\u2010Josas France"},{"name":"AgroParisTech UMR Micalis  Jouy\u2010en\u2010Josas France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gw\u00e9na\u00ebl","family":"Jan","sequence":"additional","affiliation":[{"name":"Science et Technologie du Lait et de l\u2019\u0152uf INRA  Rennes France"},{"name":"Agrocampus Ouest  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Van de Guchte","sequence":"additional","affiliation":[{"name":"INRA  Jouy\u2010en\u2010Josas France"},{"name":"AgroParisTech UMR Micalis  Jouy\u2010en\u2010Josas France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Folign\u00e9","sequence":"additional","affiliation":[{"name":"Institut Pasteur de Lille, Lactic Acid Bacteria &amp; Mucosal Immunity Center for Infection and Immunity of Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"473","article-title":"Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease","volume":"7","author":"Ghouri Y. 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