{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T08:40:54Z","timestamp":1696408854177},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NSF MRI","award":["1126373"],"award-info":[{"award-number":["1126373"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Mild dietary zinc (Zn) deficiency is wide\u2010spread in human populations, but the effect on Zn\u2010dependent processes of immune function and healing are not well understood. The consequences of mild dietary Zn restriction were examined in two mouse models of inflammation and recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Male C57BL\/6 mice were fed a Zn adequate diet (ZA, 30 mg Zn\/kg diet), or diets containing sub\u2010optimal Zn levels (ZM, 15 mg Zn\/kg diet; ZD, 10 mg Zn\/kg diet) for 30 days before a thioglycollate peritonitis challenge. Plasma lipid profiles were distinct, with greater Zn restriction resulting in a greater impact on metabolites. The milder ZM diet was selected for immune studies. Peritoneal macrophages from ZM mice displayed increased phagocytosis and amplified pro\u2010inflammatory cytokine (IL\u20101\u03b2, IL\u20106, and TNF\u03b1) release compared to ZA, at baseline and after a secondary LPS challenge. Splenocytes isolated from ZM mice displayed an increase in IL\u20106 and a reduction in anti\u2010inflammatory IL\u20104 compared to ZA. Cytokine levels in plasma were unaltered. Following mechanical manipulation of the intestines to induce ileus, ZM mice had delayed intestinal transit compared to ZA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mild Zn deficiency enhances local inflammatory responses, amplifying macrophage functions and delaying recovery from acute insults within the peritoneum.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201500688","type":"journal-article","created":{"date-parts":[[2015,12,2]],"date-time":"2015-12-02T09:14:54Z","timestamp":1449047694000},"page":"672-681","source":"Crossref","is-referenced-by-count":6,"title":["Impaired recovery from peritoneal inflammation in a mouse model of mild dietary zinc restriction"],"prefix":"10.1002","volume":"60","author":[{"given":"Brett E.","family":"Phillips","sequence":"first","affiliation":[{"name":"Departments of Surgery  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby K.","family":"Geletzke","sequence":"additional","affiliation":[{"name":"Departments of Surgery  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip B.","family":"Smith","sequence":"additional","affiliation":[{"name":"Departments of Veterinary and Biomedical Sciences  University Park PA USA"},{"name":"The Huck Institutes of the Life Sciences  University Park PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail B.","family":"Podany","sequence":"additional","affiliation":[{"name":"Departments of Surgery  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Chacon","sequence":"additional","affiliation":[{"name":"Pennsylvania State Hershey College of Medicine  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon L.","family":"Kelleher","sequence":"additional","affiliation":[{"name":"Departments of Surgery  Hershey PA USA"},{"name":"Cellular and Molecular Physiology  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Departments of Veterinary and Biomedical Sciences  University Park PA USA"},{"name":"Molecular Toxicology  University Park PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David I.","family":"Soybel","sequence":"additional","affiliation":[{"name":"Departments of Surgery  Hershey PA USA"},{"name":"Cellular and Molecular Physiology  Hershey PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1967.01330180139023"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1412S"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0209OC"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.008417"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819cefe4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/030006059202000102","article-title":"Changes in serum trace elements after surgery: value of copper and zinc in predicting post\u2010operative fatigue","volume":"20","author":"Cordova Martinez A.","year":"1992","journal-title":"J. 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