{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:48:43Z","timestamp":1787496523119,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T00:00:00Z","timestamp":1465344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003712","name":"Korea Food Research Institute","doi-asserted-by":"crossref","award":["E0150302; KIOM K14281"],"award-info":[{"award-number":["E0150302; KIOM K14281"]}],"id":[{"id":"10.13039\/501100003712","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Natural compounds that regulate peroxisome proliferator\u2010activated receptor alpha (PPAR\u03b1) have been reported to have beneficial effects in obesity\u2010mediated metabolic disorders. In this study, we demonstrated that biochanin A (BA), an agonist of PPAR\u2010\u03b1, improved hepatic steatosis and insulin resistance by regulating hepatic lipid and glucose metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      C57BL\/6 mice were fed a normal chow diet, a high\u2010fat diet (HFD), and an HFD supplemented with 0.05% BA for 12 weeks. Histological and biochemical examinations indicated that BA prevented obesity\u2010induced hepatic steatosis and insulin resistance in HFD\u2010fed mice. BA stimulated the transcriptional activation of PPAR\u2010\u03b1\n                      <jats:italic>in vitro<\/jats:italic>\n                      and increased the expression of PPAR\u2010\u03b1 and its regulatory proteins in the liver. CE\u2010TOF\/MS analyses indicated that BA administration promoted the recovery of metabolites involved in phosphatidylcholine synthesis, lipogenesis, and beta\u2010oxidation in the livers of obese mice. BA also suppressed the levels of gluconeogenesis\u2010related metabolites and the expression of the associated enzymes, glucose 6\u2010phosphatase and pyruvate kinase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taken together, these results showed that BA ameliorated metabolic disorders such as hepatic steatosis and insulin resistance by modulating lipid and glucose metabolism in diet\u2010induced obesity. Thus, BA may be a potential therapeutic agent for the prevention of obesity\u2010mediated hepatic steatosis and insulin resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201500689","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T13:09:16Z","timestamp":1462367356000},"page":"1944-1955","source":"Crossref","is-referenced-by-count":44,"title":["Biochanin A improves hepatic steatosis and insulin resistance by regulating the hepatic lipid and glucose metabolic pathways in diet\u2010induced obese mice"],"prefix":"10.1002","volume":"60","author":[{"given":"Hee\u2010Sook","family":"Park","sequence":"first","affiliation":[{"name":"Division of Nutrition and Metabolism Korea Food Research Institute  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haeng Jeon","family":"Hur","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Korea Food Research Institute  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon\u2010Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Korea Food Research Institute  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Korea Food Research Institute  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moon Ju","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Korea Food Research Institute  Seongnam Republic of Korea"},{"name":"Department of Food Biotechnology University of Science &amp; Technology  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jeong","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Korea Food Research Institute  Seongnam Republic of Korea"},{"name":"Department of Food Biotechnology University of Science &amp; Technology  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Young","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Korea Food Research Institute  Seongnam Republic of Korea"},{"name":"Department of Food Biotechnology University of Science &amp; Technology  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung\u2010Sunny","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Nutrition and Metabolism Korea Food Research Institute  Seongnam Republic of Korea"},{"name":"Department of Food Biotechnology University of Science &amp; 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