{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:52:45Z","timestamp":1791219165422,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,22]],"date-time":"2015-12-22T00:00:00Z","timestamp":1450742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"R\u00e9gion Rh\u00f4ne-Alpes ARC1"},{"name":"Lipides pour l\u2019Industrie et la Sant\u00e9 and Soci\u00e9t\u00e9 Francophone du Diab\u00e8te"},{"name":"Corinne Malpuech-Brug\u00e8re"},{"DOI":"10.13039\/100006630","name":"Utah State University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006630","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Enhanced adiposity and metabolic inflammation are major features of obesity that could be impacted by dietary emulsifiers. We investigated in high\u2010fat fed mice the effects of using a new polar lipid (PL) emulsifier from milk (MPL) instead of soybean lecithin (soybean PL [SPL]) on adipose tissue and intestinal mucosa function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Four groups of C57BL6 mice received for 8 wks a low\u2010fat (LF) diet or a high\u2010fat diet devoid of PLs or an high\u2010fat diet including MPL (high\u2010fat\u2010MPL) or SPL (high\u2010fat\u2010SPL). Compared with high\u2010fat diet, high\u2010fat\u2010SPL diet increased white adipose tissue (WAT) mass (<jats:italic>p<\/jats:italic> &lt; 0.05), with larger adipocytes (<jats:italic>p<\/jats:italic> &lt; 0.05) and increased expression of tumor necrosis factor alpha, monochemoattractant protein\u20101, LPS\u2010binding protein, and leptin (<jats:italic>p<\/jats:italic> &lt; 0.05). This was not observed with high\u2010fat\u2010MPL diet despite similar dietary intakes and increased expression of fatty acid transport protein 4 and microsomal TG transfer protein, involved in lipid absorption, in upper intestine (<jats:italic>p<\/jats:italic> &lt; 0.05). High\u2010fat\u2010MPL mice had a lower expression in WAT of cluster of differentiation 68, marker of macrophage infiltration, versus high\u2010fat and high\u2010fat\u2010SPL mice (<jats:italic>p<\/jats:italic> &lt; 0.05), and more goblet cells in the colon (<jats:italic>p<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unlike SPL, MPL in the high\u2010fat diet did not induce WAT hypertrophy and inflammation but increased colonic goblet cells. This supports further clinical exploration of different sources of dietary emulsifiers in the frame of obesity outbreak.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201500703","type":"journal-article","created":{"date-parts":[[2015,11,23]],"date-time":"2015-11-23T10:02:40Z","timestamp":1448272960000},"page":"609-620","source":"Crossref","is-referenced-by-count":85,"title":["Dietary emulsifiers from milk and soybean differently impact adiposity and inflammation in association with modulation of colonic goblet cells in high\u2010fat fed mice"],"prefix":"10.1002","volume":"60","author":[{"given":"Manon","family":"Lecomte","sequence":"first","affiliation":[{"name":"INRA UMR1397 INSERM U1060 CarMeN Laboratory INSA\u2010Lyon, IMBL, Universit\u00e9 Lyon 1  Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Cou\u00ebdelo","sequence":"additional","affiliation":[{"name":"ITERG\u2010ENMS Universit\u00e9 de Bordeaux  Talence 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