{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:49:06Z","timestamp":1790632146000,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81302426, 81220108005, 31200886"],"award-info":[{"award-number":["81302426, 81220108005, 31200886"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2013 M540762, 2015M580856"],"award-info":[{"award-number":["2013 M540762, 2015M580856"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Docosahexaenoic acid (DHA; C22: 6, <jats:italic>n<\/jats:italic>\u20103), one of PUFAs, exerts beneficial effects on inflammatory diseases, obesity and diabetes. Angiogenesis in adipose tissue has a major role in the development of obesity and its related metabolic complications. Inhibition of angiogenesis is an emerging strategy for the novel treatment for obesity. Thus, we examined the effect of DHA on angiogenesis in adipose tissues and investigated the underlying mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In high\u2010fat diet (HFD) fed middle\u2010aged mice, DHA inhibited the macrophage\u2010derived inflammation and angiogenesis in adipose tissues, reduced adipocyte size and body fat composition and improved insulin sensitivity. Moreover, DHA reversed the HFD\u2010induced reduction of Sirt1 in adipose tissues. Interestingly, the effects of DHA were attenuated by lentivirus\u2010mediated Sirt1 knockdown with increasing expression of markers of macrophage\u2010derived inflammation and angiogenesis, associated with impaired insulin sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Overall, our findings demonstrated that DHA reduced angiogenesis of adipose tissues and attenuated insulin resistance in HFD\u2010induced obese mice via the activation of Sirt1.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201500714","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T20:31:13Z","timestamp":1452457873000},"page":"871-885","source":"Crossref","is-referenced-by-count":26,"title":["Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet\u2010fed middle\u2010aged mice via a sirt1\u2010dependent mechanism"],"prefix":"10.1002","volume":"60","author":[{"given":"Xiaoqin","family":"Luo","sequence":"first","affiliation":[{"name":"Cardiovascular Research Center, School of Medicine Xi'an Jiaotong University  Xi'an P.R. China"},{"name":"Department of Medicine, School of Public Health Xi'an Jiaotong University Health Science Center  Xi'an P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center  Xi'an P.R. China"},{"name":"Department of Prosthodontics, Stomatological Hospital, College of Stomatology Xi'an Jiaotong University  Xi'an PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyu","family":"Yao","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, School of Medicine Xi'an Jiaotong University  Xi'an P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirui","family":"Xu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, School of Medicine Xi'an Jiaotong University  Xi'an P.R. 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