{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:12:31Z","timestamp":1790367151455,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FIS 2011\u201000214"],"award-info":[{"award-number":["FIS 2011\u201000214"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["FIS PI11\/210"],"award-info":[{"award-number":["FIS PI11\/210"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PI14\/290"],"award-info":[{"award-number":["PI14\/290"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Changes in genetic variations affecting the taste receptor, type 2, member 38 (TAS2R38) may identify the interacting mechanism leading to obesity and potential associations with proteins partaking in innate immunity, such as surfactant protein D (SPD) and mannan\u2010binding lectin (MBL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We evaluated haplotypes of the bitter\u2010taste receptor TAS2R38 in an identification sample of 210 women in different weight conditions, including anorexia nervosa and obesity. The association with SPD and MBL was tested in an independent sample picturing general population (<jats:italic>n<\/jats:italic> = 534). The relationship with obesity was validated in an extended final sample of 1319 participants. In the sample comprised of women in extreme weight conditions, increased obesity was identified in AVI\/AVI subjects (OR = 2.5 [1.06\u20136.11], <jats:italic>p<\/jats:italic> = 0.035). In the sample picturing general population, increased SPD and MBL concentrations were found in nonsmoking AVI carriers. In this cohort, smoking and obesity blunted associations between TAS2R38 haplotypes and SPD and MBL. In the extended sample, the association of AVI\/AVI haplotypes with increased obesity was also identified (OR = 1.4 [0.99\/1.85], <jats:italic>p<\/jats:italic> = 0.049), being more robust in subjects aged &lt;40 years (OR = 1.9 [1.06\/3.42], <jats:italic>p<\/jats:italic> = 0.031).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Current data reinforce the impact of TAS2R38 gene on phenotypic and clinical outputs affecting obesity, showing significant associations with extreme weight conditions (i.e., obesity and anorexia nervosa), and changes in both olfactory capacity and immune traits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201500804","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T12:16:15Z","timestamp":1460290575000},"page":"1673-1683","source":"Crossref","is-referenced-by-count":54,"title":["Genetic variations of the bitter taste receptor TAS2R38 are associated with obesity and impact on single immune traits"],"prefix":"10.1002","volume":"60","author":[{"given":"Francisco J.","family":"Ortega","sequence":"first","affiliation":[{"name":"CIBER de la Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBEROBN) and Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Service of Diabetes Endocrinology and Nutrition (UDEN) and Institut d'Investigaci\u00f3 Biom\u00e9dica de Girona (IdIBGi)  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaida","family":"Ag\u00fcera","sequence":"additional","affiliation":[{"name":"CIBER de la Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBEROBN) and Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Department of Psychiatry University Hospital of Bellvitge (IDIBELL), and Department of Clinical Sciences School of Medicine, University of Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f2nica","family":"Sabater","sequence":"additional","affiliation":[{"name":"CIBER de la Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBEROBN) and Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Service of Diabetes Endocrinology and Nutrition (UDEN) and Institut d'Investigaci\u00f3 Biom\u00e9dica de Girona (IdIBGi)  Girona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M","family":"Moreno\u2010Navarrete","sequence":"additional","affiliation":[{"name":"CIBER de la Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n (CIBEROBN) and Instituto de Salud Carlos III (ISCIII)  Madrid Spain"},{"name":"Service of Diabetes Endocrinology and Nutrition (UDEN) and Institut d'Investigaci\u00f3 Biom\u00e9dica de Girona (IdIBGi)  Girona 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