{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:34:45Z","timestamp":1790076885722,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/20441\u20109"],"award-info":[{"award-number":["2012\/20441\u20109"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/01288\u20100"],"award-info":[{"award-number":["2014\/01288\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,7]]},"abstract":"\n Scope<\/jats:title>\n \n Vitamin B\n 6<\/jats:sub>\n plays crucial roles on brain development and its maternal deficiency impacts the gamma\u2010aminobutyric acid (GABA)ergic, serotonergic, glutamatergic, and dopaminergic systems in offspring. However, the molecular mechanisms underlying these neurological changes are not well understood. Thus, we aimed at evaluating which components of those neurotransmitter metabolism and signaling pathways can be modulated by maternal vitamin B\n 6<\/jats:sub>\n \u2010deficient or B\n 6<\/jats:sub>\n \u2010supplementated diets in the hippocampus of rat dams and their offspring.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and results<\/jats:title>\n \n Female Wistar rats were fed three different diets: control (6 mg vitamin B\n 6<\/jats:sub>\n \/kg), supplemented (30 mg vitamin B\n 6<\/jats:sub>\n \/kg) or deficient diet (0 mg vitamin B\n 6<\/jats:sub>\n \/kg), from 4 weeks before pregnancy through lactation. Newborn pups (10 days old) from rat dams fed vitamin B\n 6<\/jats:sub>\n \u2010deficient diet presented hyperhomocysteinemia and had a significant increase in mRNA levels of glutamate decarboxylase 1 (\n Gad1<\/jats:italic>\n ), fibroblast growth factor 2 (\n Fgf2<\/jats:italic>\n ), and glutamate\u2010ammonia ligase (\n Glul<\/jats:italic>\n ), while glutaminase (\n Gls<\/jats:italic>\n ) and tryptophan hydroxylase 1 (\n Tph1<\/jats:italic>\n ) mRNAs were downregulated. Vitamin B\n 6<\/jats:sub>\n supplementation or deficiency did not change hippocampal global DNA methylation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A maternal vitamin B\n 6<\/jats:sub>\n \u2010deficient diet affects the expression of genes related to GABA, glutamate, and serotonin metabolisms in offspring by regulating\n Gad1<\/jats:italic>\n ,\n Glul<\/jats:italic>\n ,\n Gls<\/jats:italic>\n , and\n Tph1<\/jats:italic>\n mRNA expression.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mnfr.201500950","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T02:48:46Z","timestamp":1456973326000},"page":"1615-1624","source":"Crossref","is-referenced-by-count":24,"title":["Maternal vitamin B\n 6<\/sub>\n deficient or supplemented diets on expression of genes related to GABAergic, serotonergic, or glutamatergic pathways in hippocampus of rat dams and their offspring"],"prefix":"10.1002","volume":"60","author":[{"given":"Mara Ribeiro","family":"Almeida","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Department of Animal Sciences North Dakota State University Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Mabasa","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences North Dakota State University Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Crane","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences North Dakota State University Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung S","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences North Dakota State University Fargo North Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Paula","family":"Ven\u00e2ncio","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Lourdes Pires","family":"Bianchi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lus\u00e2nia Maria Greggi","family":"Antunes","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2011.05.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0954579415000061"},{"key":"e_1_2_8_4_1","first-page":"304","article-title":"Effect of pyridoxine deficiency on the structural and functional development of hippocampus","volume":"48","author":"Krishna A. P.","year":"2004","journal-title":"Indian J. Physiol. Pharmacol."},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/jn\/120.5.485","article-title":"Effects of maternal restriction in vitamin B\u20106 on neocortex development in rats: neuron differentiation and synaptogenesis","volume":"120","author":"Groziak S. M.","year":"1990","journal-title":"J. Nutr."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1972.tb01477.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1971.tb00196.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234219"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00964820"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb04111.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(91)90249-J"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.005207"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2012.02.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(00)00402-4"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200636"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.08.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00085"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830513Y.0000000097"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2015.00041"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(02)00012-X"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/717958"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2011.240291"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114511004570"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-9-49"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2004.09.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.11.1939"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-111-6_2"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201300726"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200686"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12350"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200315"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.14010004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0703806104"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/clinchem\/45.2.290","article-title":"Rapid and accurate HPLC assay for plasma total homocysteine and cysteine in a clinical laboratory setting","volume":"45","author":"Pfeiffer C. M.","year":"1999","journal-title":"Clin. Chem."},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201000300"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.05.061"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10696"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2006.04.001"},{"key":"e_1_2_8_41_1","volume-title":"The Role of Vitamin B6 in Central Nervous System Development: Neurochemistry and Behavior","author":"Guilart T. R.","year":"1995"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800649200"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9600-5"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.08.015"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.03.008"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-013-9501-5"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2013.53"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-013-1289-9"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.58"},{"key":"e_1_2_8_50_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.31887\/DCNS.2014.16.1\/adayer","article-title":"Serotonin\u2010related pathways and developmental plasticity: relevance for psychiatric disorders","volume":"16","author":"Dayer A.","year":"2014","journal-title":"Dialogues Clin. Neurosci."},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0109"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.154.10.1451"},{"key":"e_1_2_8_53_1","first-page":"7","article-title":"The methionine\u2010homocysteine cycle and its effects on cognitive diseases","volume":"8","author":"Miller A. L.","year":"2003","journal-title":"Altern. Med. Rev."},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071714-034330"}],"container-title":["Molecular Nutrition & Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201500950","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201500950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:44:36Z","timestamp":1696380276000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201500950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,29]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/mnfr.201500950"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201500950","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,29]]}}}