{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:27:37Z","timestamp":1760646457567,"version":"3.41.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Science and Technology (DST)","award":["SR\/SO\/HS-15\/2009"],"award-info":[{"award-number":["SR\/SO\/HS-15\/2009"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The present study was designed to identify the molecular mechanism of folate modulation and aging on aberrant liver folate transporter system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>An in vivo rat model was used, in which weanling, young and adult rats were given folate deficient diet for 3 and 5 months and after 3 months of folate deficiency, one group received physiological folate repletion (2 mg\/kg diet) and another group received over supplemented folate diet (8 mg\/kg diet) for another 2 months. In adult group, 3 and 5 months of folate deficiency decreased serum and tissue folate levels with decreased uptake of folate, further associated with decreased expression levels of reduced folate carrier (RFC) and increased expression levels of folate exporter (ABCG2) at both mRNA and protein levels, which in turn regulated by promoter hypermethylation of RFC and promoter hypomethylation of ABCG2 gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Promoter hypermethylation of RFC and promoter hypomethylation of ABCG2 may be attributed to the down regulation of RFC and up regulation of ABCG2 at mRNA and protein levels in conditions of 3 and 5 months of folate deficiency in the adult group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201500991","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T07:16:57Z","timestamp":1458371817000},"page":"1501-1513","source":"Crossref","is-referenced-by-count":7,"title":["Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation"],"prefix":"10.1002","volume":"60","author":[{"given":"Rauf","family":"Ahmad Najar","sequence":"first","affiliation":[{"name":"Cancer Pharmacology Division CSIR\u2010Indian Institute of Integrative Medicine Jammu India"},{"name":"Department of Biochemistry Panjab University Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beenish","family":"Rahat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aashiq","family":"Hussain","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division CSIR\u2010Indian Institute of Integrative Medicine Jammu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Thakur","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaspreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"University Institute of Engineering and Technology Panjab University Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyotdeep","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abid","family":"Hamid","sequence":"additional","affiliation":[{"name":"Cancer Pharmacology Division CSIR\u2010Indian Institute of Integrative Medicine Jammu India"},{"name":"CSIR\u2010Academy of Scientific &amp; Innovative Research New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-072610-145133"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.06959.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb01921.x"},{"key":"e_1_2_8_5_1","first-page":"145","article-title":"Alcohol interference with the folate enterohepatic cycle","volume":"90","author":"Hillman R.","year":"1977","journal-title":"Trans. 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