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Resistance to chemotherapy and radiotherapy is the major obstacle for cure of cancer. Combination of HNK with many traditional chemotherapeutic drugs as well as radiation sensitizes cancer cells to apoptotic death, suggesting that HNK not only directly inhibits primary cancers and metastasis, but also has potential to overcome drug resistance. Ultimately, this may mean that HNK could be combined with traditional chemotherapies administered at lower doses to significantly reduce toxicity, meanwhile enhance efficacy. As a natural compound, HNK is composed of polyphenols and has been described in many studies targeting multiple key cell signaling molecules. Mitochondria are the main hub for cellular energy production and play an important role in cell survival, and are the key target identified for HNK to mediate cancer cell death, survival, and metastasis. In this review, we have summarized different aspects of HNK's anti\u2010cancer effects from recent accumulated literature, as well as the underlying molecular mechanisms. This review is primarily focused on the effects of HNK on epidermal growth factor receptor (EGFR) and signal transduction and activator of transcription 3 (STAT3) signaling, as well as the broader regulation of mitochondrial function and cancer cell metabolism.<\/jats:p>","DOI":"10.1002\/mnfr.201501007","type":"journal-article","created":{"date-parts":[[2016,4,11]],"date-time":"2016-04-11T09:07:21Z","timestamp":1460365641000},"page":"1383-1395","source":"Crossref","is-referenced-by-count":50,"title":["Honokiol targets mitochondria to halt cancer progression and metastasis"],"prefix":"10.1002","volume":"60","author":[{"given":"Jing","family":"Pan","sequence":"first","affiliation":[{"name":"Medical College of Wisconsin Cancer Center and Department of Pharmacology &amp; Toxicology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongik","family":"Lee","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Cancer Center and Department of Pharmacology &amp; Toxicology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Cancer Center and Department of Pharmacology &amp; Toxicology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"You","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin Cancer Center and Department of Pharmacology &amp; Toxicology Medical College of Wisconsin  Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,6]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"17","article-title":"Natural sources as potential anti\u2010cancer agents: a review","volume":"3","author":"Abhishek Bhanot R. 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