{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:20:51Z","timestamp":1790054451141,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,4,21]],"date-time":"2016-04-21T00:00:00Z","timestamp":1461196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>We previously reported that specific <jats:italic>Lactobacillus reuteri<\/jats:italic> colonized within mouse Peyer's patches (PP) effectively prevented high fat diet induced obesity and low\u2010grade chronic inflammation. We further investigated the role of PP <jats:italic>Lactobacillus reuteri<\/jats:italic> on sIgA production in rats in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Lactobacilli were isolated from rat PP. All isolates were <jats:italic>L. reuteri<\/jats:italic> and belonged to three phenotypes according to amplified fragment length polymorphism analysis. Typical strains of two main clusters, PP1 and PP2, were used to treat control and vitamin A deficient (VAD) rats, respectively. The feeding of PP1 and PP2 affected sIgA and <jats:italic>Lactobacillus<\/jats:italic> diversity by strain\u2010specific manner. Free sIgA was significantly increased by PP1 (<jats:italic>p<\/jats:italic> = 0.069) and PP2 (<jats:italic>p<\/jats:italic> &lt; 0.05) in the control rats but not in the VAD rats. Only PP1 significantly changed PP <jats:italic>Lactobacillus<\/jats:italic> diversity in the control rats (<jats:italic>p<\/jats:italic> &lt; 0.05). However, PP2 specifically changed ileal <jats:italic>Lactobacillus<\/jats:italic> diversity in both control and VAD rats. Fecal sIgA was correlated with PP <jats:italic>Lactobacillus<\/jats:italic> diversity (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.7958, <jats:italic>p<\/jats:italic> = 0.011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Modulation of sIgA production by PP <jats:italic>L. reuteri<\/jats:italic> of rat is dependent on vitamin A and change of <jats:italic>Lactobacillus<\/jats:italic> diversity in PP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201501065","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T10:44:07Z","timestamp":1459421047000},"page":"2020-2030","source":"Crossref","is-referenced-by-count":34,"title":["Isolation of <i>lactobacillus reuteri<\/i> from Peyer's patches and their effects on sIgA production and gut microbiota diversity"],"prefix":"10.1002","volume":"60","author":[{"given":"Panpan","family":"Wang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology Jiangnan University  Wuxi PR China"},{"name":"Food Nutrition and Functional Factors Research Center School of Food Science and Technology Jiangnan University  Wuxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[{"name":"Food Nutrition and Functional Factors Research Center School of Food Science and Technology Jiangnan University  Wuxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Food Science University of Massachusetts  Amherst MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghui","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Technology Jiangnan University  Wuxi PR China"},{"name":"Food Nutrition and Functional Factors Research Center School of Food Science and Technology Jiangnan University  Wuxi 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