{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:58:15Z","timestamp":1791874695751,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,6]],"date-time":"2016-05-06T00:00:00Z","timestamp":1462492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005992","name":"Ministry of Education and Science","doi-asserted-by":"publisher","award":["AGL2009\u201013517"],"award-info":[{"award-number":["AGL2009\u201013517"]}],"id":[{"id":"10.13039\/501100005992","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Lipoprotein particle measures performed by nuclear magnetic resonance (NMR), and associated ratios, may be better markers for atherosclerosis risk than conventional lipid measures. The effect of two functional olive oils, one enriched with its polyphenols (FVOO, 500\u00a0ppm), and the other (FVOOT) with them (250\u00a0ppm) and those of thyme (250\u00a0ppm), versus a standard virgin olive oil (VOO), on lipoprotein particle atherogenic ratios and subclasses profiles was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>In a randomized, double\u2010blind, crossover, controlled trial, 33 hypercholesterolemic individuals received 25 mL\/day of VOO, FVOO, and FVOOT. Intervention periods were of 3 weeks separated by 2\u2010week washout periods. Lipoprotein particle counts and subclasses were measured by NMR. Polyphenols from olive oil and thyme modified the lipoprotein subclasses profile and decreased the total LDL particle\/total HDL particle (HDL\u2010P), small HDL\/large HDL, and HDL\u2010cholesterol\/HDL\u2010P ratios, and decreased the lipoprotein insulin resistance index (LP\u2010IR) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Olive oil polyphenols, and those from thyme provided benefits on lipoprotein particle atherogenic ratios and subclasses profile distribution. Polyphenol\u2010enriched olive oil is a way of increasing the olive oil healthy properties while consuming the same amount of fat, as well as a useful and complementary tool for the management of cardiovascular risk individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201501068","type":"journal-article","created":{"date-parts":[[2016,3,19]],"date-time":"2016-03-19T01:01:58Z","timestamp":1458349318000},"page":"1544-1554","source":"Crossref","is-referenced-by-count":54,"title":["Polyphenol rich olive oils improve lipoprotein particle atherogenic ratios and subclasses profile: A randomized, crossover, controlled trial"],"prefix":"10.1002","volume":"60","author":[{"given":"Sara","family":"Fern\u00e1ndez\u2010Castillejo","sequence":"first","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, Institut Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, NFOC group, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat Rovira i Virgili, CIBERDEM  Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa\u2010Maria","family":"Valls","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, Institut Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, NFOC group, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat Rovira i Virgili, CIBERDEM  Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Casta\u00f1er","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk and Nutrition Research group IMIM\u2010 Institut Hospital del Mar d'Investigacions M\u00e8diques, CIBEROBN  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Rubi\u00f3","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, Institut Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, NFOC group, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat Rovira i Virgili, CIBERDEM  Reus Spain"},{"name":"Food Technology Department; Agrotecnio Center University of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00darsula","family":"Catal\u00e1n","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, Institut Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, NFOC group, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat Rovira i Virgili, CIBERDEM  Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pedret","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Hospital Universitari Sant Joan, Institut Investigaci\u00f3 Sanit\u00e0ria Pere Virgili, NFOC group, Facultat de Medicina i Ci\u00e8ncies de la Salut Universitat Rovira i Virgili, CIBERDEM  Reus Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Maci\u00e0","sequence":"additional","affiliation":[{"name":"Food Technology Department; Agrotecnio Center University of Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen L.","family":"Sampson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Center National Institutes of Health  Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda\u2010Isabel","family":"Covas","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk and Nutrition Research group IMIM\u2010 Institut Hospital del Mar d'Investigacions M\u00e8diques, CIBEROBN  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Fit\u00f3","sequence":"additional","affiliation":[{"name":"Cardiovascular Risk and Nutrition Research group IMIM\u2010 Institut Hospital del Mar d'Investigacions M\u00e8diques, CIBEROBN  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria\u2010Jos\u00e9","family":"Motilva","sequence":"additional","affiliation":[{"name":"Food Technology Department; 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