{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:03:01Z","timestamp":1791252181079,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The aim of this study was to compare if lycopene also possesses pro\u2010vitamin A (VA) activity comparable to known VA derivatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We used a transgenic retinoic acid response element reporter mouse model (<jats:italic>n<\/jats:italic> = 8, per group) for this study, and after the initial wash out of VA using a vitamin A deficient diet (VAD) for 18 weeks, the animals were supplemented further with (a) VAD\u2010fed mice, (b) VAD\u2010fed mice plus retinol (20 mg\/kg bw), (c) VAD\u2010fed mice plus \u03b2\u2010carotene (40 mg\/kg bw), and (d) VAD\u2010fed mice plus lycopene (40 mg\/kg bw). Using ex vivo scanning and gene expression analysis of retinoid target and VA marker gene analysis in various organs of these supplemented mice (b, c, d), we found increased luciferase activity and normalized marker and target gene analysis compared to group a.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lycopene can restore VA deficiency and compensate VA for retinoic acid receptor (RAR)\u2010mediated signaling as the major function of VA in the mammalian organism. Lycopene administration can initiate upregulation of RAR\u2010mediated signaling in various organs in VAD\u2010fed animals via potential novel bioactive lycopene metabolites. This indicates that lycopene possesses partial pro\u2010VA activity in mice transmitted via RAR\u2010mediated signaling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600031","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T09:30:24Z","timestamp":1465896624000},"page":"2413-2420","source":"Crossref","is-referenced-by-count":28,"title":["Lycopene supplementation restores vitamin A deficiency in mice and possesses thereby partial pro\u2010vitamin A activity transmitted via RAR signaling"],"prefix":"10.1002","volume":"60","author":[{"given":"Gamze","family":"Aydemir","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Medical and Health Science Center University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasamin","family":"Kasiri","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Medical and Health Science Center University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Em\u00f6ke\u2010M\u00e1rta","family":"Bart\u00f3k","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Medical and Health Science Center University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eszter","family":"Birta","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Medical and Health Science Center University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Friedrich Schiller University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Institute of Nutrition Friedrich Schiller University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Mihaly","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Medical and Health Science Center University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"R\u00fchl","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Medical and Health Science Center University of Debrecen  Debrecen Hungary"},{"name":"Paprika Bioanalytics BT  Debrecen Hungary"},{"name":"MTA\u2010DE Public Health Research Group of the Hungarian Academy of Sciences Faculty of Public Health University Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","article-title":"Nomenclature of retinoids. 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