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Resveratrol (RV), a polyphenolic compound derived from grapes and red wine, exerts a wide range of beneficial effects via activation of sirtuin 1 (SIRT1) and induction of vitagenes. Here, we assessed the role of RV in a 1\u2010methyl\u20104\u2010phenyl\u20101, 2, 3, 6\u2010tetrahydropyridine (MPTP) induced mouse model of PD and explored its potential mechanisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>RV and EX527, a specific inhibitor of SIRT1, were administered before and after MPTP treatment. RV protected against MPTP\u2010induced loss of dopaminergic neurons, and decreases in tyrosine hydroxylase and dopamine levels, as well as behavioral impairments. Meanwhile, RV administration activated SIRT1. Microtubule\u2010associated protein 1 light chain 3 (LC3) was then deacetylated and redistributed from the nucleus to the cytoplasm, which provoked the autophagic degradation of \u03b1\u2010synuclein in dopaminergic neurons. Furthermore, EX527 antagonized the neuroprotective effects of RV by reducing LC3 deacetylation and subsequent autophagic degradation of \u03b1\u2010synuclein.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We showed that RV ameliorated both motor deficits and pathological changes in MPTP\u2010treated mice via activation of SIRT1 and subsequent LC3 deacetylation\u2010mediated autophagic degradation of \u03b1\u2010synuclein. Our observations suggest that RV may be a potential prophylactic and\/or therapeutic agent for PD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600111","type":"journal-article","created":{"date-parts":[[2016,6,14]],"date-time":"2016-06-14T09:38:02Z","timestamp":1465897082000},"page":"2161-2175","source":"Crossref","is-referenced-by-count":181,"title":["Resveratrol alleviates MPTP\u2010induced motor impairments and pathological changes by autophagic degradation of \u03b1\u2010synuclein via SIRT1\u2010deacetylated LC3"],"prefix":"10.1002","volume":"60","author":[{"given":"Yan\u2010Jie","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine  Shanghai P.R. 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