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We investigated metabolic consequences of maternal HFD in adolescent rat offspring and the potential benefic effects of fish oil (FO) (<jats:italic>n<\/jats:italic>\u20103 polyunsaturated fatty acid source).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Female rats received isocaloric, standard diet (STD: 9% fat) or HFD (28.6%) before mating, and throughout pregnancy and lactation. After weaning, male offspring received standard diet and, from 25th to 45th day, received oral administration of soybean oil (SO) or FO. HFD offspring showed higher body weight and adiposity, which was not attenuated by FO. In STD offspring, FO reduced serum triglyceride and cholesterol, as expected, but not in HFD offspring. Liver of HFD offspring groups showed increased free cholesterol and FO\u2010treated HFD group showed lower expression of <jats:italic>Abcg8<\/jats:italic>, suggesting decreased cholesterol biliary excretion. HFD offspring presented higher hepatic expression of lipogenic markers, <jats:italic>Srebf1<\/jats:italic> mRNA and acetyl CoA carboxylase (ACC). Serum <jats:italic>n<\/jats:italic>\u20103 PUFA were decreased in FO\u2010treated HFD compared to FO\u2010treated STD offspring, which may explain the reduced hypolipidemic FO effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal HFD impaired the ability of FO to reduce adiposity and serum lipids in adolescent offspring, suggesting a potential predisposition to future development of metabolic disorders<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600171","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T08:32:46Z","timestamp":1466843566000},"page":"2493-2504","source":"Crossref","is-referenced-by-count":25,"title":["Perinatal maternal high\u2010fat diet promotes alterations in hepatic lipid metabolism and resistance to the hypolipidemic effect of fish oil in adolescent rat offspring"],"prefix":"10.1002","volume":"60","author":[{"given":"Lorraine S.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho Universidade Federal do Rio de Janeiro  RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana L.","family":"Souza","sequence":"additional","affiliation":[{"name":"Instituto de Biof\u00edsica Carlos Chagas Filho Universidade Federal do Rio de Janeiro  RJ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline F. 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