{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:48:08Z","timestamp":1790772488014,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T00:00:00Z","timestamp":1478822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>The stimulation of the free fatty acid receptor G\u2010protein coupled receptor (GPR) 40 by GW9508 prevents bone loss by inhibiting osteoclast activity, both in vitro and in vivo. Here, we questioned whether the stimulation of the GPR40 receptor by dietary fatty acids may lead to the same beneficial effect on bone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We investigated (i) the impact of a fatty acid enriched diet (high\u2010fat diet [HFD]) on bone health in C57\/BL6 female mice depending on (ii) the estrogen status (ovariectomy) and (iii) the genotype (GPR40<jats:sup>+\/+<\/jats:sup> or GPR40<jats:sup>\u2212\/\u2212<\/jats:sup>). Bone mineral density (BMD), body composition, weight, inflammation and bone remodeling parameters were monitored. HFD decreased BMD in HFD\u2010SH\u2010GPR40<jats:sup>+\/+<\/jats:sup> mice but OVX failed to further impact BMD in HFD\u2010OVX\u2010GPR40<jats:sup>+\/+<\/jats:sup>mice, while additional bone loss was observed in HFD\u2010OVX\u2010GPR40<jats:sup>\u2212\/\u2212<\/jats:sup> animals. These data suggest that when stimulated by fatty acid enriched diets GPR40 contributes to counteract ovariectomy\u2010induced bone alteration. The sparing effect is supported by the modulation of both the osteoprotegerin\/receptor activator of nuclear factor kappa\u2010B ligand (OPG\/RANKL) ratio in blood stream and the expression level of inflammatory markers in adipose tissues. Bone preservation by GPR40 stimulation is dependent on the presence of long\u2010chain saturated fatty acids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>GPR40 contributes to counter ovariectomy\u2010induced bone loss in a context of saturated fatty acid enrichment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600219","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T19:06:19Z","timestamp":1473447979000},"source":"Crossref","is-referenced-by-count":13,"title":["GPR40 mediates potential positive effects of a saturated fatty acid enriched diet on bone"],"prefix":"10.1002","volume":"61","author":[{"given":"Claire","family":"Philippe","sequence":"first","affiliation":[{"name":"INRA UMR 1019 UNH CRNH Auvergne  Clermont\u2010Ferrand France"},{"name":"Clermont Universit\u00e9 Universit\u00e9 d'Auvergne, Unit\u00e9 de Nutrition Humaine  Clermont\u2010Ferrand France"},{"name":"Equipe Alimentation Squelette et M\u00e9tabolismes Unit\u00e9 de Nutrition Humaine Centre de Recherche INRA Auvergne Rh\u00f4ne Alpes Site de Theix  63122 Saint Gen\u00e9s Champanelle France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Wauquier","sequence":"additional","affiliation":[{"name":"INRA UMR 1019 UNH CRNH Auvergne  Clermont\u2010Ferrand France"},{"name":"Clermont Universit\u00e9 Universit\u00e9 d'Auvergne, Unit\u00e9 de Nutrition Humaine  Clermont\u2010Ferrand France"},{"name":"Equipe Alimentation Squelette et M\u00e9tabolismes Unit\u00e9 de Nutrition Humaine Centre de Recherche INRA Auvergne Rh\u00f4ne Alpes Site de Theix  63122 Saint Gen\u00e9s Champanelle France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Landrier","sequence":"additional","affiliation":[{"name":"INRA UMR1260, Nutriments Lipidiques et Pr\u00e9vention des Maladies M\u00e9taboliques  Marseille France"},{"name":"Facult\u00e9 de M\u00e9decine Universit\u00e9 de la 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