{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T13:51:40Z","timestamp":1781013100698,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31201020"],"award-info":[{"award-number":["31201020"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Myricetin is found in most berries, vegetables, and various medicinal herbs, which has been reported to possess various bio\u2010activities. However, the role of myricetin on liver fibrosis remains to be elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Hepatic stellate cell (HSC) line CFSC\u20108B was stimulated by transforming growth factor \u03b21 (TGF\u2010\u03b21) or platelet\u2010derived growth factor BB (PDGF\u2010BB) to induce liver fibrosis in vitro. The results showed that myricetin significantly ameliorated TGF\u2010\u03b21\u2010 or PDGF\u2010BB\u2010induced HSCs activation, cell migration, and extracellular matrix production; blocked TGF\u2010\u03b21\u2010induced phosphorylation of Smad2, P38, extracellular signal\u2010regulated kinase (ERK), and protein kinase B (Akt); and downregulated PDGF\u2010BB stimulated phosphorylation of extracellular signal\u2010regulated kinase and Akt in HSCs in a dose\u2010dependent manner. Meanwhile, the carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>) induced mouse model has been used to study antifibrosis role of myricetin in vivo. Our data demonstrated that myricetin suppressed \u03b1\u2010smooth muscle actin and collagen type I deposition and blocked phosphorylation of Smad2, mitogen\u2010activated protein kinases, and Akt in CCl<jats:sub>4<\/jats:sub>\u2010treated mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Myricetin inhibits the activation of HSCs and ameliorates CCl<jats:sub>4<\/jats:sub>\u2010induced liver fibrosis in mice and may serve as a potential therapeutic agent in the treatment of liver fibrosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600392","type":"journal-article","created":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T16:09:20Z","timestamp":1481990960000},"source":"Crossref","is-referenced-by-count":42,"title":["The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice"],"prefix":"10.1002","volume":"61","author":[{"given":"Yan","family":"Geng","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010Ming","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Yu","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Song","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science Jiangnan University  Wuxi Jiangsu China"},{"name":"Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2741\/A812"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.02.033"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1663"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.04.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.276.4.G1059"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.150"},{"key":"e_1_2_8_9_1","first-page":"72","article-title":"Targeted therapies in liver fibrosis: combining the best parts of platelet\u2010derived growth factor bb and interferon gamma","volume":"2","author":"Dijk F.","year":"2015","journal-title":"Front. 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