{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:13:29Z","timestamp":1791947609148,"version":"4.3.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T00:00:00Z","timestamp":1482105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015120","name":"DAIKO FOUNDATION","doi-asserted-by":"crossref","award":["9158"],"award-info":[{"award-number":["9158"]}],"id":[{"id":"10.13039\/100015120","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Grants-in-Aid for Scientific Research from the Japan Society for Promotion of Science","award":["26450168"],"award-info":[{"award-number":["26450168"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:title>Scope<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 (GLP\u20101) is a type of incretin secreted from enteroendocrine L\u2010cells. Our previous studies demonstrated that curcumin (a yellow pigment of turmeric) significantly increases the secretion of GLP\u20101 in enteroendocrine L cell line (GLUTag cells). However, it is not clear whether its action in vivo directly enhances GLP\u20101 secretion, which then leads to a reduction in blood glucose levels via the stimulation of insulin secretion. In addition, the molecular target of curcumin\u2010induced GLP\u20101 secretion has not been clarified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Glucose tolerance was significantly improved in rats after pre\u2010administered curcumin (1.5 mg\/kg) followed by intraperitoneal glucose injections via the stimulation of GLP\u20101 secretion and the induction of insulin secretion. In GLUTag cells, curcumin\u2010induced GLP\u20101 secretion was associated with G protein\u2010coupled receptor (GPR) 40\/120. Furthermore, the glucose\u2010lowering effect induced by curcumin was significantly reduced after the administration of a GPR40\/120 antagonist in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings demonstrate the biological function of curcumin as a GLP\u20101 secretagogue and the possible molecular target that mediates GLP\u20101 secretion. Increases in the secretion of endogenous GLP\u20101 induced by curcumin may allow the dosages of other diabetic medicines to be reduced and aid in the prevention of diabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mnfr.201600471","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T12:46:19Z","timestamp":1478522779000},"source":"Crossref","is-referenced-by-count":89,"title":["Curcumin improves glucose tolerance via stimulation of glucagon\u2010like peptide\u20101 secretion"],"prefix":"10.1002","volume":"61","author":[{"given":"Masaki","family":"Kato","sequence":"first","affiliation":[{"name":"College of Bioscience and Biotechnology Chubu University  Kasugai Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"College of Bioscience and Biotechnology Chubu University  Kasugai Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiho","family":"Ikehata","sequence":"additional","affiliation":[{"name":"College of Bioscience and Biotechnology Chubu University  Kasugai Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojiro","family":"Dochi","sequence":"additional","affiliation":[{"name":"College of Bioscience and Biotechnology Chubu University  Kasugai Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsubasa","family":"Tani","sequence":"additional","affiliation":[{"name":"College of Bioscience and Biotechnology Chubu University  Kasugai Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Theravalues Corporation  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"Theravalues Corporation  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Tsuda","sequence":"additional","affiliation":[{"name":"College of Bioscience and Biotechnology Chubu University  Kasugai Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21030264"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0116"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112855"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91194-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.1.124"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2007.02333.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201400871"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.04.092"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.660"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO00032C"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.8.12.1646"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126157"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.11.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0307"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1168"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05648.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9432-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.03.010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phanu.2015.08.002"}],"container-title":["Molecular Nutrition &amp; Food Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201600471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmnfr.201600471","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mnfr.201600471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T08:03:53Z","timestamp":1695024233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mnfr.201600471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/mnfr.201600471"],"URL":"https:\/\/doi.org\/10.1002\/mnfr.201600471","archive":["Portico"],"relation":{},"ISSN":["1613-4125","1613-4133"],"issn-type":[{"value":"1613-4125","type":"print"},{"value":"1613-4133","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,19]]},"article-number":"1600471"}}